Effect of Calcium‐Fortified Potato Starch on Cecal Fermentation and Fat Accumulation in Rats
Effect of Calcium‐Fortified Potato Starch on Cecal Fermentation and Fat Accumulation in Rats
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加钙马铃薯淀粉对大鼠盲肠发酵和脂肪积累的影响
DOI：
10.1002/star.202000097
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Fukushima Michihiro
中科院分区：
文献类型：
--
作者：
Nagata Ryuji;Taneda Kotomi;Pelpolage Samanthi Wathsala;Bochimoto Hiroki;Fukuma Naoki;Shimada Kenichiro;Tani Masayuki;Han Kyu‐Ho;Fukushima Michihiro
将钙强化马铃薯淀粉（Ca-PS）喂给大鼠四周，并评价对盲肠发酵和脂质代谢的影响。假长双歧杆菌在大鼠盲肠中的相对丰度在PS和Ca-PS组中高于对照组。Ca-PS组的盲肠乙酸酯含量高于对照组、高直链玉米淀粉（HAS）组和PS组，且与B的相对丰度呈正相关。假舌PS和Ca-PS组中梭菌家族的相对丰度高于对照组和HAS组，并且与盲肠钙丁酸含量和总SCFA中正丁酸的摩尔比例呈正相关。此外，PS和Ca-PS的消耗降低了大鼠的血清和肝脏甘油三酯水平以及肠系膜脂肪细胞面积。因此，Ca-PS可能具有增强盲肠发酵的有益作用，特别是在盲肠乙酸盐产生方面，这进一步抑制了脂肪积累。这是第一项报道Ca-PS生理效应的研究。
Calcium‐fortified potato starch (Ca‐PS) is fed to rats for four weeks, and the effects on cecal fermentation and lipid metabolism are evaluated. The relative abundance ofBifidobacterium pseudolongumin rat cecum is higher in the PS and Ca‐PS groups than in the control group. Cecal acetate content is higher in the Ca‐PS group than in the control, high‐amylose cornstarch (HAS), and PS groups, and is positively correlated with the relative abundance ofB. pseudolongum. The relative abundance of theClostridiaceaefamily is higher in the PS and Ca‐PS groups than in the control and HAS groups, and is positively correlated with the cecaln‐butyrate content and the molar proportion ofn‐butyrate in total‐SCFA. Furthermore, the consumption of PS and Ca‐PS reduces the serum and hepatic triglyceride levels and mesenteric adipocyte area in rats. Therefore, Ca‐PS may have beneficial effects that enhance cecal fermentation, especially in terms of cecal acetate production, which further suppresses fat accumulation. This is the first study to report the physiological effects of Ca‐PS.
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