Methods for Detecting Mycobacterial Mixed Strain Infections-A Systematic Review.
Methods for Detecting Mycobacterial Mixed Strain Infections-A Systematic Review.
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DOI：
10.3389/fgene.2020.600692
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发表时间：
2020
影响因子：
3.7
通讯作者：
Tahlan K
中科院分区：
文献类型：
--
作者：
Byrne AS;Goudreau A;Bissonnette N;Shamputa IC;Tahlan K
混合菌株感染（MSI）是指易感宿主同时感染同一病原种的多种菌株。已知发生在人类和动物中，当研究分枝杆菌疾病的传播动力学、进化和治疗时，特别是人类的结核病和反刍动物的副结核病（或约翰氏病）时，MSI值得特别考虑。因此，进行了一项系统性综述，以检查文献中如何定义MSI，该现象在宿主物种谱中有多普遍，并记录用于检测此类感染的常用方法。我们的检索策略确定了121篇报告人类和动物MSI的文章，其中大多数（78.5%）涉及结核分枝杆菌复合体的成员，而只有少数（21.5%）研究了非结核分枝杆菌（NTM）。此外，MSI存在于各种宿主物种中，但由于对结核病的大量研究，大多数报告都集中在人类身上。我们回顾了允许MSI检测的菌株分型方法，发现了一些常用但与特定挑战相关的方法。我们的评论指出，需要标准化，因为一些高度歧视的方法不适合区分一个菌株的微进化和并发感染多个菌株。还需要进一步研究以检查NTM MSI在人类和动物中的患病率。此外，据设想，准确识别和更好地了解未来的MSI的分布将导致重要的信息，分枝杆菌疾病的流行病学和病理生理学。
Mixed strain infection (MSI) refers to the concurrent infection of a susceptible host with multiple strains of a single pathogenic species. Known to occur in humans and animals, MSIs deserve special consideration when studying transmission dynamics, evolution, and treatment of mycobacterial diseases, notably tuberculosis in humans and paratuberculosis (or Johne's disease) in ruminants. Therefore, a systematic review was conducted to examine how MSIs are defined in the literature, how widespread the phenomenon is across the host species spectrum, and to document common methods used to detect such infections. Our search strategy identified 121 articles reporting MSIs in both humans and animals, the majority (78.5%) of which involved members of the Mycobacterium tuberculosis complex, while only a few (21.5%) examined non-tuberculous mycobacteria (NTM). In addition, MSIs exist across various host species, but most reports focused on humans due to the extensive amount of work done on tuberculosis. We reviewed the strain typing methods that allowed for MSI detection and found a few that were commonly employed but were associated with specific challenges. Our review notes the need for standardization, as some highly discriminatory methods are not adapted to distinguish between microevolution of one strain and concurrent infection with multiple strains. Further research is also warranted to examine the prevalence of NTM MSIs in both humans and animals. In addition, it is envisioned that the accurate identification and a better understanding of the distribution of MSIs in the future will lead to important information on the epidemiology and pathophysiology of mycobacterial diseases.
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影响因子：
4.6
作者：
Abascal, Estefania;Herranz, Marta;Garcia de Viedma, Dario
通讯作者：
Garcia de Viedma, Dario
影响因子：
9.4
作者：
Amonsin, A;Li, LL;Kapur, V
通讯作者：
Kapur, V
DOI：
10.1016/j.tube.2015.07.004
发表时间：
2015-12
期刊：
Tuberculosis (Edinburgh, Scotland)
影响因子：
--
作者：
Adami AJ;Cervantes JL
通讯作者：
Cervantes JL
影响因子：
3.7
作者：
Bryant JM;Schürch AC;van Deutekom H;Harris SR;de Beer JL;de Jager V;Kremer K;van Hijum SA;Siezen RJ;Borgdorff M;Bentley SD;Parkhill J;van Soolingen D
通讯作者：
van Soolingen D
影响因子：
3.7
作者：
Ahmed, Imran;Jabeen, Kauser;Hasan, Rumina
通讯作者：
Hasan, Rumina