Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group.

Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group.
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DOI:
10.1016/j.neuroimage.2017.02.030
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发表时间:
2017-06
期刊:
影响因子:
5.7
通讯作者:
Wardlaw JM
Wardlaw JM
中科院分区:
医学1区
文献类型:
--
作者:
BRAINS (Brain Imaging in Normal Subjects) Expert Working Group;Shenkin SD;Pernet C;Nichols TE;Poline JB;Matthews PM;van der Lugt A;Mackay C;Lanyon L;Mazoyer B;Boardman JP;Thompson PM;Fox N;Marcus DS;Sheikh A;Cox SR;Anblagan D;Job DE;Dickie DA;Rodriguez D;Wardlaw JM

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脑成像现在在临床实践和研究中无处不在。现在,将特征清晰的健康受试者和一生中患有一系列常见脑部疾病的受试者的大量图像数据汇集在一起的情况令人信服。该报告是在来自多个学科的国际专家会议之后发表的,这些专家都对脑图像生物银行感兴趣。参加会议的有神经成像专家(临床和非临床)、计算机科学家、流行病学家、临床医生、伦理学家和参与创建脑图像库的律师。会议采用结构化的形式,讨论当前和新兴的脑图像库;地图集等应用程序;概念和统计问题(如定义“常态”);法律、伦理和技术问题(例如,同意、数据链接的潜力、数据安全、协调、数据存储和使研究数据共享成为可能)。我们总结了从广泛的个人图像库的经验中吸取的教训,并提供了切实可行的建议,以加强神经成像数据的创建、使用和重用。我们的目标是最大限度地利用由研究参与者自愿提供并由许多组织资助的图像数据,以促进人类健康。我们的最终愿景是建立一个大脑图像生物库的联合网络,用于对大脑结构和功能的大规模研究。
Brain imaging is now ubiquitous in clinical practice and research. The case for bringing together large amounts of image data from well-characterised healthy subjects and those with a range of common brain diseases across the life course is now compelling. This report follows a meeting of international experts from multiple disciplines, all interested in brain image biobanking. The meeting included neuroimaging experts (clinical and non-clinical), computer scientists, epidemiologists, clinicians, ethicists, and lawyers involved in creating brain image banks. The meeting followed a structured format to discuss current and emerging brain image banks; applications such as atlases; conceptual and statistical problems (e.g. defining ‘normality’); legal, ethical and technological issues (e.g. consents, potential for data linkage, data security, harmonisation, data storage and enabling of research data sharing). We summarise the lessons learned from the experiences of a wide range of individual image banks, and provide practical recommendations to enhance creation, use and reuse of neuroimaging data. Our aim is to maximise the benefit of the image data, provided voluntarily by research participants and funded by many organisations, for human health. Our ultimate vision is of a federated network of brain image biobanks accessible for large studies of brain structure and function.
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