Comparison of the behavioral and cardiovascular effects of mephedrone with other drugs of abuse in rats.
Comparison of the behavioral and cardiovascular effects of mephedrone with other drugs of abuse in rats.
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DOI：
10.1007/s00213-012-2855-1
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发表时间：
2013-02
影响因子：
3.4
通讯作者：
Winsauer, Peter J.
中科院分区：
文献类型：
--
作者：
Varner, Kurt J.;Daigle, Kyle;Weed, Peter F.;Lewis, Peter B.;Mahne, Sarah E.;Sankaranarayanan, Ananthakrishnan;Winsauer, Peter J.
Exceedingly little experimental research exists on the popular recreational drug mephedrone (4-methylmethcathinone) despite clinical reports concerning its behavioral and cardiovascular toxicity. To characterize mephedrone preclinically by examining its capacity to: 1) serve as a discriminative stimulus, 2) disrupt the acquisition of response sequences, and 3) disrupt mean arterial pressure (MAP) and heart rate (HR). In one group of subjects that reliably discriminated 3.2 mg/kg of mephedrone from saline (n=9), substitution tests indicated that stimulants (cocaine, MDMA and methamphetamine) more closely approximated the mephedrone discriminative stimulus than non-stimulants (fenfluramine, morphine, and phencyclidine), although none fully substituted. In a second group (n=6), mephedrone (0.56–10 mg/kg, i.p.) dose-dependently decreased response rate and increased errors in both components of a procedure in which subjects either acquired a new response sequence each session (repeated acquisition) or completed the same response sequence each session (performance). Finally, in a third group (n=12), radio telemetry probes were used to measure the changes in MAP and HR elicited by mephedrone and then compared them to a known stimulant, methamphetamine. In these studies, mephedrone (0.01–9 mg/kg, i.v.) elicited increases in MAP and HR that were very similar to those elicited by methamphetamine (0.01–9 mg/kg, i.v.). The tachycardia and pressor responses to mephedrone (3 mg/kg) were blocked by the β-blocker atenolol (1 mg/kg, i.v.) and the α1, α2-blocker phentolamine (3 mg/kg, i.v.), respectively. Mephedrone produces behavioral and cardiovascular responses that are similar to other stimulants; however, differences from the classical stimulants were also apparent.
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DOI：
10.1016/j.pbb.2009.09.010
发表时间：
2009-12
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Galizio M;McKinney P;Cerutti DT;Pitts RC
通讯作者：
Pitts RC
影响因子：
4.7
作者：
Angoa-Pérez M;Kane MJ;Francescutti DM;Sykes KE;Shah MM;Mohammed AM;Thomas DM;Kuhn DM
通讯作者：
Kuhn DM
影响因子：
3.6
作者：
GLENNON, RA;YOUNG, R;MCKENNEY, JD
通讯作者：
MCKENNEY, JD
影响因子：
7.3
作者：
Kehr, J.;Ichinose, F.;Yoshitake, T.
通讯作者：
Yoshitake, T.
影响因子：
3.1
作者：
Regan, Luke;Mitchelson, Mark;Macdonald, Catriona
通讯作者：
Macdonald, Catriona