Effects of MDMA, methamphetamine and methylphenidate on repeated acquisition and performance in rats.
Effects of MDMA, methamphetamine and methylphenidate on repeated acquisition and performance in rats.
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DOI：
10.1016/j.pbb.2009.09.010
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Pitts RC
中科院分区：
文献类型：
--
作者：
Galizio M;McKinney P;Cerutti DT;Pitts RC
重复的收购程序，包括性能控制的影响，不特定于收购允许评估药物对学习的影响，在受试者内，在会话的基础上。尽管这种方法的优点，很少有研究探讨精神兴奋剂对啮齿动物重复收购的影响。本研究的目的是研究亚甲二氧基甲基苯丙胺（MDMA，0.3-10 mg/kg），甲基苯丙胺（MA，0.1-3 mg/kg）和哌醋甲酯（MPD，1-17 mg/kg）的影响，使用重复采集程序与性能控制在大鼠中使用触摸屏装置。使用计算机触摸屏向大鼠提供2 × 3的刺激阵列，并加强对阵列内目标位置的鼻戳。在获取组件中，正确的位置在各个会话中发生变化，而在性能组件中，正确的位置在各个会话中保持不变。所有三种药物都以剂量依赖性方式降低了对靶位置的响应准确性。这些化合物在任何剂量下都没有增强学习能力。MPD和MA仅在也破坏性能的剂量下产生显著的采集准确性破坏，但3 mg/kg剂量的MDMA损害了目标响应的采集而不影响性能。在本研究中发现的选择性损害的收购增加了急性MDMA管理产生的学习和记忆中断的证据，并提出了这些行动的机制的问题。
Repeated-acquisition procedures that include performance controls for effects not specific to acquisition permit the assessment of drug effects on learning on a within-subject, within-session basis. Despite the advantages of this methodology, few studies have examined effects of psychomotor stimulants on repeated acquisition in rodents. The purpose of the present study was to investigate the effects of methylenedioxymethamphetamine (MDMA, 0.3-10 mg/kg), methamphetamine (MA, 0.1-3 mg/kg) and methylphenidate (MPD,1-17 mg/kg) using repeated-acquisition procedures with performance controls in rats using a touch-screen apparatus. Rats were presented a 2 × 3 array of stimuli using a computer touch-screen and nose-pokes to target locations within the array were reinforced. In the acquisition component, the correct location changed across sessions, whereas during the performance component, the correct location was constant across sessions. All three drugs reduced accuracy of responding to target locations in a dose-dependent fashion. None of the compounds enhanced learning at any dose. MPD and MA produced significant disruptions of acquisition accuracy only at doses that also disrupted performance, but the 3 mg/kg dose of MDMA impaired acquisition of target responding without affecting performance. The selective impairment of acquisition found in the present study adds to the evidence of learning and memory disruption produced by acute MDMA administration and raise questions about the mechanisms for these actions.
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