Toxicity of quantum dots on respiratory system
Toxicity of quantum dots on respiratory system
复制标题
量子点对呼吸系统的毒性
DOI：
10.3109/08958378.2013.871762
复制
发表时间：
2014-02
影响因子：
2.1
通讯作者：
Tang M
中科院分区：
文献类型：
--
作者：
Wu T;Tang M
摘要量子点作为一种先进的纳米技术产品，因其独特的性质被广泛应用于生物医学领域的诊断和治疗。因此，阐明量子点对人体的不良影响变得十分重要。本文综述了量子点对呼吸系统的毒性作用，主要分为两个部分：体外毒性，包括细胞活力降低、遗传物质损伤和免疫细胞反应紊乱；体内毒性，包括量子点蓄积、肺损伤和炎症，以及潜在的长期不良反应。由于量子点类型的毒性程度取决于其组成、剂量、大小、表面化学和结构，因此确定量子点的基准是一个巨大的挑战。因此，我们必须记住，每一种量子点类型都是唯一的纳米晶体，需要单独评估。然而，在这篇综述中仍然有一些可行的建议来将毒性降到最低。总体而言，需要进行越来越多的大规模、有组织的不同类型的量子点对不同物种的毒性研究，以便为量子点的安全应用提供指导。
Abstract Quantum dots (QDs), as advanced nanotechnology products, are widely used in the bio-medical field for diagnostic and therapeutic purposes due to their unique properties. Therefore, it becomes important for researchers to elucidate the adverse effects of QDs on human beings. This essay provides an overview of the toxic effects of QDs on respiratory system, which are summarized into two main parts: in vitro toxicity, including reduction of cell viability, genetic material damage and disordered immune cell reactions; as well as in vivo toxicity, involving accumulation of QDs, lung injury and inflammation, and potential long-term adverse effects. As the toxic severity of a QD type depends on its composition, dose, size, surface chemistry and structure, it is a big challenge to determine a benchmark of QDs. Thus, we have to remember that each QD type is a unique nanocrystal, which needs to be assessed individually. However, there are still some feasible recommendations for minimizing the toxicity provided in this review. Overall, more and more large-scale well-organized toxicity studies of different QD types on different species need to be conducted in order to provide guidelines of QDs’ safety application.
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影响因子：
10
作者：
Jacobsen NR;Møller P;Jensen KA;Vogel U;Ladefoged O;Loft S;Wallin H
通讯作者：
Wallin H
影响因子：
10.4
作者：
Hardman R
通讯作者：
Hardman R
影响因子：
3.9
作者：
Bonner JC
通讯作者：
Bonner JC
影响因子：
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作者：
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通讯作者：
Chung, Hai Won
影响因子：
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作者：
B. Eichler;P. Power
通讯作者：
B. Eichler;P. Power