Carbon nanotubes as delivery systems for respiratory disease: do the dangers outweigh the potential benefits?
Carbon nanotubes as delivery systems for respiratory disease: do the dangers outweigh the potential benefits?
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DOI：
10.1586/ers.11.72
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发表时间：
2011-12
影响因子：
3.9
通讯作者：
Bonner JC
中科院分区：
文献类型：
--
作者：
Bonner JC
纳米颗粒给药系统提供了改善治疗效果的潜力，然而也存在与这些新的治疗策略相关的潜在风险。碳纳米管（CNTs）的一个吸引人的特性是其管状或纤维状结构允许广泛的功能化和装载货物。然而，大量证据表明，如果将碳纳米管用于给药，可能会产生不良影响，因为已证明碳纳米管会导致肺纤维化，并加剧已有肺部疾病的啮齿动物的肺部疾病。造成这些毒性作用的主要因素是高长径比、耐久性和产生活性氧的残余金属含量。因此，应仔细考虑肺部炎症或纤维化可能是由基于碳纳米管的药物传递系统引起的显著副作用的可能性，从而超过治疗治疗的任何潜在有益效果。然而，通过功能化碳纳米管来调节长径比、生物降解性和去除残留金属，可以在某些情况下安全设计用于给药的碳纳米管。
Nanoparticle drug-delivery systems offer the potential for improved efficacy of treatment, and yet there are also potential risks associated with these novel therapeutic strategies. An attractive property of carbon nanotubes (CNTs) is that the tube- or fiber-like structure allows for extensive functionalization and loading of cargo. However, a large body of evidence indicates that CNTs may have adverse effects if used in drug delivery as they have been shown to cause pulmonary fibrosis and exacerbate lung disease in rodents with pre-existing lung diseases. Major factors that cause these toxic effects are the high aspect ratio, durability and residual metal content that generate reactive oxygen species. Therefore, careful consideration should be given to the possibility that lung inflammation or fibrosis could be significant side effects caused by a CNT-based drug-delivery system, thereby outweighing any potential beneficial effects of therapeutic treatment. However, functionalization of CNTs to modulate aspect ratio, biodegradability and to remove residual metals could allow for safe design of CNTs for use in drug delivery in certain circumstances.
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影响因子：
3.2
作者：
Inoue, Ken-ichiro;Takano, Hirohisa;Shimada, Akinori
通讯作者：
Shimada, Akinori
影响因子：
17.1
作者：
George, Saji;Pokhrel, Suman;Xia, Tian;Gilbert, Benjamin;Ji, Zhaoxia;Schowalter, Marco;Rosenauer, Andreas;Damoiseaux, Robert;Bradley, Kenneth A.;Maedler, Lutz;Nel, Andre E.
通讯作者：
Nel, Andre E.
影响因子：
10.8
作者：
Erdely, Aaron;Hulderman, Tracy;Simeonova, Petia P.
通讯作者：
Simeonova, Petia P.
影响因子：
10
作者：
Jaspers I;Sheridan PA;Zhang W;Brighton LE;Chason KD;Hua X;Tilley SL
通讯作者：
Tilley SL
DOI：
10.1513/pats.200907-061rm
发表时间：
2010-05-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Bonner, James C
通讯作者：
Bonner, James C