Correlation between apparent diffusion coefficient and tumor-stroma ratio in hybrid (18)F-FDG PET/MRI: preliminary results of a rectal cancer cohort study.
Correlation between apparent diffusion coefficient and tumor-stroma ratio in hybrid (18)F-FDG PET/MRI: preliminary results of a rectal cancer cohort study.
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DOI：
10.21037/qims-21-938
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发表时间：
2022-08
影响因子：
2.8
通讯作者：
Du, Xiaohui
中科院分区：
文献类型：
--
作者：
Hu, Shidong;Xing, Xiaowei;Liu, Jiajin;Liu, Xi;Li, Jinhang;Jin, Wei;Li, Songyan;Yan, Yang;Teng, Da;Liu, Boyan;Wang, Yufeng;Xu, Baixuan;Du, Xiaohui
关键词：
探讨未经治疗的直肠癌患者的肿瘤间质比（TSR）与氟-18-氟脱氧葡萄糖正电子发射断层扫描/磁共振成像（18 F-FDG PET/MRI）的不同成像特征之间的可能相关性。本研究纳入了直肠癌患者。所有参与者术前均接受全身18F-FDG PET/MRI检查。两名病理学家一起评估肿瘤的TSR。测量并比较高基质组和低基质组原发病灶的表观扩散系数（ADC）值和PET相关参数。采用Pearson相关或斯皮尔曼等级相关分析ADC值、PET相关参数和病理指标之间的相关性。我们的结果显示，在未经治疗的直肠癌患者中，ADC平均值与TSR相关（r=0.327; P=0.007），并且基质高（低TSR）直肠癌对应于相对较低的ADC平均值（813.54±88.68 vs. 879.92±133.18; P=0.018）。发现ADC平均值和ADC最小值（ADC最小值）与直肠癌的病理T分期（分别为r=-0.384，P=0.001; r=-0.416，P=0.001）以及最大肿瘤直径（分别为r=-0.340，P=0.005; r=-0.314，P=0.010）呈负相关。此外，病理T分期与所有PET相关代谢参数相关，包括平均标准摄取值（SUV）、最大SUV（SUVmax）、代谢肿瘤体积（MTV）和总病变糖酵解（TLG）（r=0.338，P=0.006; r=0.350，P=0.004; r=0.326，P=0.007; r=0.472，P<0.001）。我们的研究结果还确定了ADC最小值与SUV平均值、SUV最大值和TLG之间的相关性（分别为r=-0.335，P=0.006; r=-0.343，P=0.005; r=-0.343，P=0.005）。然而，PET/MRI参数与免疫组化（IHC）结果之间无统计学相关性。这项研究表明，通过PET/MRI测量的肿瘤内异质性可能反映肿瘤微环境的特征。因此，PET/MRI参数可能有助于预测肿瘤的侵袭性和预后。
To explore possible correlations between the tumor-stroma ratio (TSR) and different imaging features of fluorine-18-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) in untreated rectal cancer patients. A patients with rectal cancer were included in this study. All participants were examined preoperatively with whole-body 18F-FDG PET/MRI. Two pathologists evaluated the TSR of tumors together. Apparent diffusion coefficient (ADC) values and PET-related parameters of the primary lesions were measured and compared between the stroma-high and stroma-low groups. Pearson’s correlation or Spearman’s rank correlation were used to evaluate the correlation between the ADC values, PET-related parameters, and pathological indices. Our results showed that in the untreated rectal cancer patients, the ADC mean values correlated with the TSR (r=0.327; P=0.007), and stroma-high (low TSR) rectal cancer corresponded to relatively lower ADC mean values (813.54±88.68 vs. 879.92±133.18; P=0.018). The ADC mean and ADC minimum (ADCmin) values were found to be negatively correlated with the pathological T stages (r=−0.384, P=0.001; r=−0.416, P=0.001, respectively) as well as the largest tumor diameters (r=−0.340, P=0.005; r=−0.314, P=0.010, respectively) of rectal cancer. In addition, the pathological T stages correlated with all PET-related metabolic parameters, including mean standard uptake value (SUV), maximum SUV (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) (r=0.338, P=0.006; r=0.350, P=0.004; r=0.326, P=0.007; and r=0.472, P<0.001, respectively). Our results also identified associations between the ADCmin values and SUVmean, SUVmax, and TLG (r=−0.335, P=0.006; r=−0.343, P=0.005; and r=−0.343, P=0.005, respectively). However, there were no statistical correlations between the PET/MRI parameters and the immunohistochemical (IHC) results. This study indicated that the intratumoral heterogeneity measured by PET/MRI may reflect characteristics of the tumor microenvironment. Hence, PET/MRI parameters might be helpful in predicting tumor aggressiveness and prognosis.
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1.6
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Kang S;Na Y;Joung SY;Lee SI;Oh SC;Min BW
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Min BW
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