Lung inflammation and simulated airway resistance in infants with cystic fibrosis.
Lung inflammation and simulated airway resistance in infants with cystic fibrosis.
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DOI：
10.1016/j.resp.2021.103722
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发表时间：
2021-11
影响因子：
2.3
通讯作者：
AREST CF
中科院分区：
文献类型：
--
作者：
DeBoer EM;Kimbell JS;Pickett K;Hatch JE;Akers K;Brinton J;Hall GL;King L;Ramanauskas F;Rosenow T;Stick SM;Tiddens HA;Ferkol TW;Ranganathan SC;Davis SD;AREST CF
囊性纤维化(CF)以小气道疾病为特征，但中央呼吸道也可能受到影响。我们假设计算流体动力学(CFD)方法估计的CF患儿的呼吸道阻力高于对照组，并且CF患儿的早期呼吸道炎症与呼吸道阻力有关。根据18例CF患儿和7例对照组的胸部CT扫描，建立了中央气道模型，每个模型的中位数为51个支气管口(四分位数范围为46，56)。对进入气管的稳态气流进行模拟，以估算每个模型中的中心气道阻力。与对照组相比，患有CF的婴儿的全气道模型和减少33条支气管者的模型中，呼吸道阻力增加。呼吸道阻力与大约8个月前获得的支气管肺泡灌洗液中的炎症标志物有关，但与同时获得的标志物无关。综上所述，CFD模型估算的CFD模型显示，与对照组相比，CFD患儿的呼吸道阻力增加，可能与早期的呼吸道炎症有关。
Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance. Central airway models with a median of 51 bronchial outlets per model (interquartile range 46,56) were created from chest computed tomography scans of 18 infants with CF and 7 controls. Steady state airflow into the trachea was simulated to estimate central airway resistance in each model. Airway resistance was increased in the full airway models of infants with CF versus controls and in models trimmed to 33 bronchi. Airway resistance was associated with markers of inflammation in bronchoalveolar lavage fluid obtained approximately 8 months earlier but not with markers obtained at the same time. In conclusion, airway resistance estimated by CFD modeling is increased in infants with CF compared to controls and may be related to early airway inflammation.
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影响因子：
10
作者：
Brennan, S;Hall, GL;Sly, PD
通讯作者：
Sly, PD
影响因子：
3.1
作者：
Pittman, Jessica E.;Johnson, Robin C.;Davis, Stephanie D.
通讯作者：
Davis, Stephanie D.
影响因子：
5.8
作者：
Ranganathan, Sarath;Linnane, Barry;Hall, Graham
通讯作者：
Hall, Graham
影响因子：
3.9
作者：
Simpson SJ;Mott LS;Esther CR Jr;Stick SM;Hall GL
通讯作者：
Hall GL
影响因子：
9.6
作者：
Mott, Lauren S.;Graniel, Karla G.;Stick, Stephen M.
通讯作者：
Stick, Stephen M.