Prognostic significance of matrix metalloproteinase-7 (MMP-7) expression at the invasive front in gastric carcinoma.
Prognostic significance of matrix metalloproteinase-7 (MMP-7) expression at the invasive front in gastric carcinoma.
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DOI：
10.1111/j.1349-7006.2002.tb02171.x
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发表时间：
2002-03
期刊：
影响因子：
--
通讯作者：
Sasaki K
中科院分区：
文献类型：
--
作者：
Liu XP;Kawauchi S;Oga A;Tsushimi K;Tsushimi M;Furuya T;Sasaki K
为探讨基质金属蛋白酶-7（MMP-7）在胃癌组织中的表达及其临床病理意义，我们采用免疫组化方法检测了214例胃癌组织中MMP-7的表达，并分析了其与胃癌临床病理参数及患者预后的关系。MMP-7主要在癌细胞中表达，并且MMP-7阳性肿瘤细胞优先出现在浸润较深的巢中，尤其是在浸润前沿。在浸润或穿透固有肌层的肿瘤和II-IV期中，浸润前沿的平均MMP-7标记指数（LI）分别显著高于粘膜下层和I期（P<0.001）。统计学分析显示，214例浸润前沿MMP-7 LI与淋巴结转移、血管浸润、淋巴管浸润相关（均P<0.05），浸润前沿MMP-7高表达者预后明显差于MMP-7低表达者（P<0.01）。多因素分析显示，TNM分期和浸润前沿MMP-7表达状态是独立的预后因素（分别为P=0.0017，RR =3.12; P=0.0019，RR=2.67）。我们的研究结果表明，MMP-7在浸润前沿的表达与局部浸润密切相关，可能是胃癌患者可靠的预后指标。
To evaluate the clinicopathological significance of matrix metalloproteinase‐7 (MMP‐7) expression in gastric carcinoma, we investigated immunohistochemically MMP‐7 expression in 214 gastric carcinomas, and examined its relations with the clinicopathologic parameters including patient prognosis. MMP‐7 expressed predominantly in cancer cells, and MMP‐7‐positive tumor cells were preferentially found in deeply invading nests, especially at the invasive front. The mean MMP‐7 labeling index (LI) at the invasive front was significantly higher in tumors invading or penetrating the muscularis propria and in stages II‐IV than within the submucosal layer and in stage I, respectively (P<0.001). Statistical analysis revealed that MMP‐7 LI at the invasive front was related to lymph node metastasis, vascular invasion, and lymphatic permeation, when all 214 cases were examined as one group (P<0.05 for all), and the cases with high MMP‐7 expression at the invasive front showed significantly more unfavorable prognosis as compared with that of low MMP‐7 expression tumors (P<0.01). Multivariate analysis revealed that TNM stage and MMP‐7 expression status at the invasive front were independent prognostic factors (P=0.0017, relative risk (RR)=3.12; P=0.0019, RR=2.67, respectively). Our findings indicated that expression of MMP‐7 at the invasive front is closely associated with local invasiveness, and might be a reliable prognostic marker for patients with gastric carcinoma.
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影响因子：
6.4
作者：
Liu, XP;Kawauchi, S;Sasaki, K
通讯作者：
Sasaki, K
DOI：
10.1006/bbrc.1994.2503
发表时间：
1994-10-28
影响因子：
3.1
作者：
SIRES, UI;MURPHY, G;SENIOR, RM
通讯作者：
SENIOR, RM
影响因子：
6.2
作者：
Kawauchi, S;Goto, Y;Sasaki, K
通讯作者：
Sasaki, K
DOI：
10.1073/pnas.90.24.11767
发表时间：
1993-12-15
影响因子：
11.1
作者：
MIYAZAKI, K;KIKKAWA, Y;UMEDA, M
通讯作者：
UMEDA, M
影响因子：
24.5
作者：
Honda, M;Mori, M;Akiyoshi, T
通讯作者：
Akiyoshi, T