Correlation between colonic motility and defecatory disorders after anterior resection of the rectum in canine models
Correlation between colonic motility and defecatory disorders after anterior resection of the rectum in canine models
复制标题
犬模型直肠前切除术后结肠运动与排便障碍的相关性
DOI：
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发表时间：
2008
影响因子：
3.5
通讯作者：
H. Kuwano
中科院分区：
文献类型：
--
作者：
Y. Tabe;E. Mochiki;H. Ando;T. Ohno;Y. Kamiyama;Ryuusuke Aihara;Takaharu Fukasawa;Kaori Tsuboi;S. Yamaguchi;Souichi Tsutsumi;T. Asao;H. Kuwano
摘要本研究的目的是描述四种实验性犬模型结肠运动变化与排便障碍的相关性，重点是去神经支配。因此，我们将20只健康的杂种狗分为对照组、去神经控制组、横断组和直肠前切除术组（去神经控制加横断），构建了一个模型，并通过统计结肠迁移运动复合体（CMMCs）和结肠非迁移运动复合体（CNMCs）来关注结肠运动与排便障碍的相关性。用应变式力传感器在计算机上连续记录胃肠和结肠的收缩活动。每天检查狗的粪便，并将其稠度记录为正常，半固体或水样。与对照组相比，横断组繁殖时间延长（P < 0.05），去神经支配组C4、C5结肠收缩活性的平均运动指数大于对照组（P < 0.05）。AR组结肠运动表现出三个特征：(1)CMMC平均周期延长（P < 0.05）；（ii）繁殖时间缩短（P < 0.05）；（iii） cnmc数量的增加。关于粪便稠度，AR组仅出现水样腹泻。总之，我们揭示了排便障碍与结肠运动变化之间存在相关性。提高结直肠外科医生对结直肠手术后结肠运动变化的认识是非常重要的，这可能导致患者排便障碍的减少。
Abstract The objective of this study was to describe the correlation between changes in colonic motility and defecatory disorders in four experimental canine models, with an emphasis on denervation. Therefore, we constructed a model by dividing 20 healthy mongrel dogs into four groups, i.e. control, denervation, transection and anterior resection of the rectum (AR) (denervation plus transection), and focused on the correlation between colonic motility and defecatory disorders by counting the colonic migrating motor complexes (CMMCs) and colonic non‐migrating motor complexes (CNMCs). Gastrointestinal and colonic contractile activities were continuously recorded on a computer with strain gauge force transducers. The dogs’ feces were checked daily, and their consistency was recorded as normal, semisolid, or watery. Compared with the control group, the transection group showed elongation of the propagation time (P < 0.05), and the mean motility index of colonic contractile activity at C4 and C5 in the denervation group was greater than that in the control group (P < 0.05). The AR group showed three features of colonic motility: (i) elongation of the mean CMMC cycle (P < 0.05); (ii) shortening of the propagation time (P < 0.05); and (iii) increment of the number of CNMCs. Concerning fecal consistency, the AR group only showed watery diarrhoea. In conclusion, we revealed the existence of a correlation between defecatory disorders and changes in colonic motility. Increased knowledge among colorectal surgeons of the changes in colonic motility that occur following colorectal surgery is very important and could lead to the curtailment of defecatory disorders among patients.
腹下神经活动在负鼠肛门内括约肌功能中的作用：手术和化学去神经的影响。
DOI：
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发表时间：
1994
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Shibamoto,T;Chakder,S;Rattan,S
通讯作者：
Rattan,S
狗结肠排便时出现巨大的迁移性收缩。
影响因子：
29.4
作者：
Karaus,M;Sarna,SK
通讯作者：
Sarna,SK
液体灌注和清洁对犬结肠运动活动的影响。
DOI：
10.1152/ajpgi.1992.262.1.g62
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Sarna,SK
通讯作者：
Sarna,SK