Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes.
Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes.
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DOI：
10.2337/dc10-2415
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发表时间：
2011-07
期刊：
影响因子：
16.2
通讯作者：
Look AHEAD Research Group
中科院分区：
文献类型：
--
作者：
Wing RR;Lang W;Wadden TA;Safford M;Knowler WC;Bertoni AG;Hill JO;Brancati FL;Peters A;Wagenknecht L;Look AHEAD Research Group
超重和肥胖的人被鼓励减轻5-10%的体重，以改善心血管疾病（CVD）的风险，但支持这一建议的数据有限，特别是对于2型糖尿病患者。我们对“展望未来”项目的参与者进行了观察分析，（糖尿病健康行动）研究（n = 5 145，40.5%为男性，37%来自少数民族/种族）并检查了1年时体重减轻的幅度和CVD危险因素的变化之间的关系，以及满足2型糖尿病患者危险因素临床显著改善的预定标准的几率。糖尿病1年时体重减轻的幅度与BMI、血压、甘油三酯和HDL胆固醇的改善密切相关（P < 0.0001），但与LDL胆固醇无关（P = 0.79）。与体重稳定的参与者相比，那些体重下降5%至<10%的人体重（[平均值± SD] 7.25 ± 2.1 kg）的受试者实现HbA 1c降低0.5%的几率增加（比值比3.52 [95%CI 2.81-4.40]），舒张压下降5 mmHg（1.48 [1.20-1.82]），收缩压降低5 mmHg（1.56 [1.27-1.91]）、HDL胆固醇升高5 mg/dL（1.69 [1.37-2.07]）和甘油三酯降低40 mg/dL（2.20 [1.71-2.83]）。在大多数危险因素中临床显著改善的几率在体重减轻10-15%的人中更大。5至<10%的适度体重减轻与1年时CVD风险因素的显著改善相关，但较大的体重减轻具有更大的益处。
Overweight and obese individuals are encouraged to lose 5–10% of their body weight to improve cardiovascular disease (CVD) risk, but data supporting this recommendation are limited, particularly for individuals with type 2 diabetes. We conducted an observational analysis of participants in the Look AHEAD (Action For Health in Diabetes) study (n = 5,145, 40.5% male, 37% from ethnic/racial minorities) and examined the association between the magnitude of weight loss and changes in CVD risk factors at 1 year and the odds of meeting predefined criteria for clinically significant improvements in risk factors in individuals with type 2 diabetes. The magnitude of weight loss at 1 year was strongly (P < 0.0001) associated with improvements in glycemia, blood pressure, tryiglycerides, and HDL cholesterol but not with LDL cholesterol (P = 0.79). Compared with weight-stable participants, those who lost 5 to <10% ([means ± SD] 7.25 ± 2.1 kg) of their body weight had increased odds of achieving a 0.5% point reduction in HbA1c (odds ratio 3.52 [95% CI 2.81–4.40]), a 5-mmHg decrease in diastolic blood pressure (1.48 [1.20–1.82]), a 5-mmHg decrease in systolic blood pressure (1.56 [1.27–1.91]), a 5 mg/dL increase in HDL cholesterol (1.69 [1.37–2.07]), and a 40 mg/dL decrease in triglycerides (2.20 [1.71–2.83]). The odds of clinically significant improvements in most risk factors were even greater in those who lost 10–15% of their body weight. Modest weight losses of 5 to <10% were associated with significant improvements in CVD risk factors at 1 year, but larger weight losses had greater benefits.
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DOI：
10.1002/j.1550-8528.1999.tb00699.x
发表时间：
1999-03-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Wadden, TA;Anderson, DA;Foster, GD
通讯作者：
Foster, GD
影响因子：
--
作者：
WING, RR;KOESKE, R;BECKER, D
通讯作者：
BECKER, D
影响因子：
--
作者：
Horvath, Karl;Jeitler, Klaus;Siebenhofer, Andrea
通讯作者：
Siebenhofer, Andrea
DOI：
10.1056/nejmoa0804748
发表时间：
2009-02-26
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sacks FM;Bray GA;Carey VJ;Smith SR;Ryan DH;Anton SD;McManus K;Champagne CM;Bishop LM;Laranjo N;Leboff MS;Rood JC;de Jonge L;Greenway FL;Loria CM;Obarzanek E;Williamson DA
通讯作者：
Williamson DA
影响因子：
158.5
作者：
Sjöström, L;Lindroos, AK;Wedel, H
通讯作者：
Wedel, H