Severe hippocampal atrophy is not associated with depression in temporal lobe epilepsy.
Severe hippocampal atrophy is not associated with depression in temporal lobe epilepsy.
复制标题
严重的海马萎缩与颞叶癫痫的抑郁无关。
DOI：
10.1016/j.yebeh.2014.02.034
复制
发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Gilliam FG
中科院分区：
文献类型：
--
作者：
Hecimovic H;Santos J;Price JL;Sheline YI;Mintun MA;Snyder AZ;Christensen JJ;Carter J;Vahle V;Gilliam FG
颞叶癫痫（TLE）患者的抑郁是常见的，是主观残疾的强有力预测因素，并且可能具有独特的病理生理学特征。先前的研究表明海马体积减小与TLE患者的显著抑郁症状相关。我们利用高分辨率脑MRI的感兴趣区域分析和可靠有效的抑郁症状测量来评估28例连续的成人受试者，这些受试者具有视频/EEG证实的TLE。感兴趣的区域是基于先前对情绪和行为功能障碍的人类和动物研究。整个小组中有43%的人有明显的抑郁症状，由贝克抑郁量表（BDI）评分大于15定义。在BDI< 15的组中，总海马体积显著较小（p< 0.007）。在左海马体积最小的四分位数中，没有一个受试者的BDI评分大于15，而在上三个四分位数中，有57%的受试者的BDI评分大于15（p< 0.008）。我们评估的其他边缘系统脑结构：杏仁核、胼胝体下回、膝下回、直回或总脑容量与抑郁症状无关。足够的海马完整性可能是必要的，以维持抑郁症状的内侧颞叶癫痫。这一发现也支持了内侧颞叶癫痫中抑郁症的独特机制的可能性，例如对边缘系统网络的过度兴奋神经元影响。
Depression in temporal lobe epilepsy (TLE) is common, is a strong predictor of subjective disability, and may have unique pathophysiological characteristics. Previous studies showed that reduced hippocampal volume is associated with significant depressive symptoms in TLE patients. We utilized regions of interest analysis of high-resolution brain MRI and a reliable and valid measure of depressive symptoms to evaluate 28 consecutive adult subjects with video/EEG confirmed TLE. Regions of interest were based on prior human and animal studies of mood and behavioral dysfunction. Forty-three percent of the entire group had significant symptoms of depression, defined by a Beck Depression Inventory (BDI) score of greater than 15. Total hippocampal volumes were significantly smaller in the group with BDI< 15, (p< 0.007). None of the subjects in the quartile with the smallest left hippocampal volume had a BDI score greater than 15, compared to 57% of the subjects in the upper three quartiles (p< 0.008). No other limbic brain structures that we assessed: amygdala, subcallosal gyrus, subgenual gyrus, gyrus rectus, or total cerebral volume, were associated with depressive symptoms. Adequate hippocampal integrity may be necessary to maintain depression symptoms in mesial temporal lobe epilepsy. This finding also supports the possibility of a unique mechanism for depression in mesial temporal lobe epilepsy, such as hyerexcitable neuronal influence on the limbic network.
登录
查看更多内容
影响因子：
3.4
作者：
JAY, TM;THIERRY, AM;GLOWINSKI, J
通讯作者：
GLOWINSKI, J
DOI：
10.1073/pnas.0337481100
发表时间：
2003-02-04
影响因子：
11.1
作者：
MacQueen, GM;Campbell, S;Young, LT
通讯作者：
Young, LT
影响因子：
16.2
作者：
Mayberg, HS;Lozano, AM;Kennedy, SH
通讯作者：
Kennedy, SH
影响因子：
9.9
作者：
Kanner, A. M.;Byrne, R.;Frey, M.
通讯作者：
Frey, M.
影响因子：
9.9
作者：
Gilliam, F. G.;Maton, B. M.;Kuzniecky, R. I.
通讯作者：
Kuzniecky, R. I.