Dysfunctional proinflammatory high-density lipoproteins confer increased risk of atherosclerosis in women with systemic lupus erythematosus.
Dysfunctional proinflammatory high-density lipoproteins confer increased risk of atherosclerosis in women with systemic lupus erythematosus.
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功能障碍的促炎高密度脂蛋白赋予了全身性红斑狼疮女性动脉粥样硬化的风险。
DOI：
10.1002/art.24677
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发表时间：
2009-08
影响因子：
--
通讯作者：
Hahn, Bevra H.
中科院分区：
文献类型：
--
作者：
McMahon, Maureen;Grossman, Jennifer;Skaggs, Brian;FitzGerald, John;Sahakian, Lori;Ragavendra, Nagesh;Charles-Schoeman, Christina;Watson, Karol;Wong, Weng Kee;Volkmann, Elizabeth;Chen, Weiling;Gorn, Alan;Karpouzas, George;Weisman, Michael;Wallace, Daniel J.;Hahn, Bevra H.
患有系统性红斑狼疮(SLE)的女性会增加动脉粥样硬化。系统性红斑狼疮的高危患者的识别和动脉粥样硬化的病因仍然难以确定。正常的高密度脂蛋白在炎症过程中会失去抗氧化能力，而这些功能失调的高密度脂蛋白可能更容易导致动脉粥样硬化。本研究的目的是确定功能失调的促炎性高密度脂蛋白(PiHDL)是否与SLE的亚临床动脉粥样硬化相关。276名系统性红斑狼疮患者接受了颈动脉超声检查以识别斑块并测量内中膜厚度(IMT)。通过加入受试者高密度脂蛋白后低密度脂蛋白氧化的改变来衡量高密度脂蛋白的抗氧化功能。两种抗炎高密度脂蛋白成分对氧磷酶和载脂蛋白A-1也进行了检测。48.2%的患者存在高密度脂蛋白。有斑块的受试者中有86.7%的人有高密度脂蛋白，而没有斑块的受试者中有40.7%(p<；0.001)。患有高密度脂蛋白的患者也有较高的IMT(p<；0.001)。经多因素分析，与斑块相关的因素仅有高密度脂蛋白(OR16.1，p<；0.001)、年龄(OR1.2，p<；0.001)、高血压(OR3.0，p=0.04)、血脂异常(OR3.4，p=0.04)和混合种族背景(OR8.3，p=0.04)。与最高四分位数的IMT测量相关的因素是高密度脂蛋白(OR2.5，p=0.02)、年龄(OR1.1，p<；0.001)、体重指数(OR1.07，p=0.04)、终生泼尼松剂量20g(OR2.8，p=0.04)和非裔美国人(OR8.3，p=0.001)。功能失调的高密度脂蛋白极大地增加了SLE亚临床动脉粥样硬化的风险；它们与颈动脉斑块的增加和高IMT有关。高密度脂蛋白的存在可能有助于识别动脉粥样硬化的风险。
Women with systemic lupus erythematosus (SLE) have increased atherosclerosis. Identification of at-risk patients and the etiology underlying atherosclerosis in SLE remains elusive. Normal HDL lose antioxidant capacity during inflammation, and these dysfunctional HDL might predispose to atherosclerosis. The aim of this study is to determine whether dysfunctional pro-inflammatory HDL (piHDL) is associated with subclinical atherosclerosis in SLE. 276 SLE women had carotid artery ultrasound to identify plaques and measure intima-media thickness (IMT). Antioxidant function of HDL was measured as change in oxidation of LDL after addition of subject HDL. Two anti-inflammatory HDL components, paraoxonase and apolipoprotein A-1, were also measured. 48.2% of patients had piHDL. 86.7% of subjects with plaque had piHDL, versus 40.7% without (p<0.001). Patients with piHDL also had higher IMT (p<0.001). After multivariate analysis, the only significant factors associated with plaque were piHDL, (OR 16.1, p<0.001), age (OR 1.2, p<0.001), hypertension (OR 3.0, p=0.04), dyslipidemia (OR 3.4, p=0.04), and mixed racial background (OR 8.3, p=0.04). Factors associated with IMT measurements in the highest quartile were piHDL (OR 2.5, p=0.02), age (OR 1.1, p<0.001), body mass index (OR 1.07, p=0.04), lifetime prednisone dose > 20g (OR 2.8, p=0.04), and African American race (OR 8.3, p=0.001). Dysfunctional piHDL greatly increases risk for subclinical atherosclerosis in SLE; they associate with increased prevalence of carotid plaque and with high IMT. The presence of piHDL may help identify patients at risk for atherosclerosis.
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DOI：
10.1196/annals.1422.009
发表时间：
2007-01-01
期刊：
AUTOIMMUNITY, PT D
影响因子：
--
作者：
Kiss, Emese;Seres, Ildiko;Paragh, Gyoegy
通讯作者：
Paragh, Gyoegy
影响因子：
5.3
作者：
Holvoet, Paul;Jenny, Nancy S.;Jacobs, David R.
通讯作者：
Jacobs, David R.
影响因子：
37.8
作者：
Bild, DE;Detrano, R;Saad, MF
通讯作者：
Saad, MF
DOI：
10.1161/01.atv.15.11.1987
发表时间：
1995-11-01
影响因子：
8.7
作者：
COCKERILL, GW;RYE, KA;BARTER, PJ
通讯作者：
BARTER, PJ
影响因子：
19.6
作者：
Kalantar-Zadeh, K.;Kopple, J. D.;Navab, M.
通讯作者：
Navab, M.