The Zika Virus Epidemic in Brazil: From Discovery to Future Implications.
The Zika Virus Epidemic in Brazil: From Discovery to Future Implications.
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DOI：
10.3390/ijerph15010096
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发表时间：
2018-01-09
影响因子：
--
通讯作者：
Carvalho MS
中科院分区：
文献类型：
--
作者：
Lowe R;Barcellos C;Brasil P;Cruz OG;Honório NA;Kuper H;Carvalho MS
2015年5月，巴西东北部报告了美洲首例寨卡病毒感染确诊病例，尽管系统发育研究表明病毒早在2013年就已传入。寨卡病毒迅速蔓延到巴西和美洲大陆的其他50多个国家和地区。埃及伊蚊被认为是造成该病毒广泛传播的主要媒介。但也有性传播的报告。这一爆发性流行病对人口健康产生了不同的影响，与格林-巴利综合征病例和新生儿小头畸形和其他神经损伤的意外流行病同时发生。这导致巴西在2015年11月宣布进入全国公共卫生紧急状态，三个月后世界卫生组织也做出了类似的决定。虽然登革热病毒血清型花了几十年时间才在巴西传播，但寨卡病毒疫情在几个月内扩散，超出了登革热永久传播的区域，该区域受到南部气候屏障和北部低人口密度地区的限制。这种迅速传播可能是多种因素综合作用的结果，包括大量易感人口、有利于蚊子病媒的气候条件、其他非病媒传播以及人口高度移动的。疫情现已消退，但许多悬而未决的问题仍然存在。在这篇文章中，我们概述了寨卡病毒在巴西的发现，包括其出现和传播，流行病学监测，媒介和非媒介传播途径，临床并发症和社会经济影响。我们讨论了知识的差距和未来的挑战，以预测，预防和控制巴西和世界各地新出现和重新出现的虫媒病毒流行病。
The first confirmed case of Zika virus infection in the Americas was reported in Northeast Brazil in May 2015, although phylogenetic studies indicate virus introduction as early as 2013. Zika rapidly spread across Brazil and to more than 50 other countries and territories on the American continent. The Aedes aegypti mosquito is thought to be the principal vector responsible for the widespread transmission of the virus. However, sexual transmission has also been reported. The explosively emerging epidemic has had diverse impacts on population health, coinciding with cases of Guillain–Barré Syndrome and an unexpected epidemic of newborns with microcephaly and other neurological impairments. This led to Brazil declaring a national public health emergency in November 2015, followed by a similar decision by the World Health Organization three months later. While dengue virus serotypes took several decades to spread across Brazil, the Zika virus epidemic diffused within months, extending beyond the area of permanent dengue transmission, which is bound by a climatic barrier in the south and low population density areas in the north. This rapid spread was probably due to a combination of factors, including a massive susceptible population, climatic conditions conducive for the mosquito vector, alternative non-vector transmission, and a highly mobile population. The epidemic has since subsided, but many unanswered questions remain. In this article, we provide an overview of the discovery of Zika virus in Brazil, including its emergence and spread, epidemiological surveillance, vector and non-vector transmission routes, clinical complications, and socio-economic impacts. We discuss gaps in the knowledge and the challenges ahead to anticipate, prevent, and control emerging and re-emerging epidemics of arboviruses in Brazil and worldwide.
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影响因子：
2.1
作者：
Braks, MAH;Honório, NA;Lounibos, LP
通讯作者：
Lounibos, LP
DOI：
10.1056/nejmoa1602412
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brasil P;Pereira JP Jr;Moreira ME;Ribeiro Nogueira RM;Damasceno L;Wakimoto M;Rabello RS;Valderramos SG;Halai UA;Salles TS;Zin AA;Horovitz D;Daltro P;Boechat M;Raja Gabaglia C;Carvalho de Sequeira P;Pilotto JH;Medialdea-Carrera R;Cotrim da Cunha D;Abreu de Carvalho LM;Pone M;Machado Siqueira A;Calvet GA;Rodrigues Baião AE;Neves ES;Nassar de Carvalho PR;Hasue RH;Marschik PB;Einspieler C;Janzen C;Cherry JD;Bispo de Filippis AM;Nielsen-Saines K
通讯作者：
Nielsen-Saines K
影响因子：
3.8
作者：
Carvalho DO;McKemey AR;Garziera L;Lacroix R;Donnelly CA;Alphey L;Malavasi A;Capurro ML
通讯作者：
Capurro ML
影响因子：
3.8
作者：
Abad-Franch F;Zamora-Perea E;Ferraz G;Padilla-Torres SD;Luz SL
通讯作者：
Luz SL
影响因子：
19
作者：
Amraoui, F.;Atyame-Nten, C.;Failloux, A. B.
通讯作者：
Failloux, A. B.