Suppression of a Field Population of Aedes aegypti in Brazil by Sustained Release of Transgenic Male Mosquitoes.
Suppression of a Field Population of Aedes aegypti in Brazil by Sustained Release of Transgenic Male Mosquitoes.
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DOI：
10.1371/journal.pntd.0003864
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发表时间：
2015
影响因子：
3.8
通讯作者：
Capurro ML
中科院分区：
文献类型：
--
作者：
Carvalho DO;McKemey AR;Garziera L;Lacroix R;Donnelly CA;Alphey L;Malavasi A;Capurro ML
登革热的负担日益加重，传统的病媒控制方案相对失败，突出表明需要开发新的控制方法。使用自限性遗传技术的SIT就是这样一种有前途的方法。埃及伊蚊的一个自限性菌株OX 513 A已进入现场评估阶段。OX 513 A Ae的持续释放埃及男性导致80%的抑制目标野生Ae。2010年开曼群岛的埃及人口。在这里，我们描述了OX 513 A Ae的一系列持续的田间释放。巴西巴伊亚，茹阿泽罗郊区的埃及男性。这项研究持续了一年多，减少了当地的Ae。与邻近的无释放控制区相比，根据成虫诱捕器数据，埃及伊蚊种群减少了95%（95% CI：92.2%-97.5%），根据诱蚊产卵器指数减少了81%（95% CI：74.9-85.2%）。释放雄性动物的交配竞争力（0.031; 95% CI：0.025-0.036）与Cayman试验中估计的结果（0.059; 95% CI：0.011 - 0.210）相似，表明环境和靶菌株差异对OX 513 A雄性动物的交配成功率几乎没有影响。我们的结论是，持续释放的OX 513 A男性可能是一种有效的和广泛有用的方法，用于抑制的关键登革热载体Ae。埃及人。观察到的抑制水平可能足以在测试地区和其他传播相似或较低的地区预防登革热流行。登革热是一种主要的蚊媒疾病，其流行率和严重程度都在增加;目前没有特效药或许可的疫苗。它主要由一种蚊子传播，埃及伊蚊。我们在巴西城市茹阿泽罗的郊区Itaberaba释放了转基因“不育”雄蚊。这些雄性的后代由于转基因修饰通常在成年前死亡，持续释放这些雄性强烈抑制了目标野生种群根据不同的测量方法，抑制了80-95%。这些数据与开曼群岛先前发布的数据一致，表明两个地点之间的差异，包括环境或野生蚊子菌株，几乎没有什么区别。数学模型表明，这种程度的抑制将非常有效地防止登革热流行。
The increasing burden of dengue, and the relative failure of traditional vector control programs highlight the need to develop new control methods. SIT using self-limiting genetic technology is one such promising method. A self-limiting strain of Aedes aegypti, OX513A, has already reached the stage of field evaluation. Sustained releases of OX513A Ae. aegypti males led to 80% suppression of a target wild Ae. aegypti population in the Cayman Islands in 2010. Here we describe sustained series of field releases of OX513A Ae. aegypti males in a suburb of Juazeiro, Bahia, Brazil. This study spanned over a year and reduced the local Ae. aegypti population by 95% (95% CI: 92.2%-97.5%) based on adult trap data and 81% (95% CI: 74.9-85.2%) based on ovitrap indices compared to the adjacent no-release control area. The mating competitiveness of the released males (0.031; 95% CI: 0.025-0.036) was similar to that estimated in the Cayman trials (0.059; 95% CI: 0.011 – 0.210), indicating that environmental and target-strain differences had little impact on the mating success of the OX513A males. We conclude that sustained release of OX513A males may be an effective and widely useful method for suppression of the key dengue vector Ae. aegypti. The observed level of suppression would likely be sufficient to prevent dengue epidemics in the locality tested and other areas with similar or lower transmission. Dengue is a major mosquito-borne disease, increasing in prevalence and severity; there are no specific drugs or licensed vaccine. It is primarily transmitted by one mosquito species, Aedes aegypti. We released transgenic ‘sterile’ male mosquitoes in Itaberaba, a suburb of Juazeiro, a Brazilian city. Sustained release of these males, whose offspring typically die before adulthood as a consequence of the transgenic modification, strongly suppressed the target wild population—by 80–95% according to different measures. These data are consistent with previous releases in the Cayman Islands, suggesting that differences between the two locations, including the environment or wild mosquito strain, made little difference. Mathematical models suggest that this degree of suppression would be highly effective in preventing epidemic dengue.
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影响因子：
3
作者：
Catteruccia F;Crisanti A;Wimmer EA
通讯作者：
Wimmer EA
影响因子：
5.4
作者：
Phuc HK;Andreasen MH;Burton RS;Vass C;Epton MJ;Pape G;Fu G;Condon KC;Scaife S;Donnelly CA;Coleman PG;White-Cooper H;Alphey L
通讯作者：
Alphey L
影响因子：
46.9
作者：
Harris, Angela F.;Nimmo, Derric;Alphey, Luke
通讯作者：
Alphey, Luke
影响因子：
3.7
作者：
Lacroix R;McKemey AR;Raduan N;Kwee Wee L;Hong Ming W;Guat Ney T;Rahidah A A S;Salman S;Subramaniam S;Nordin O;Hanum A T N;Angamuthu C;Marlina Mansor S;Lees RS;Naish N;Scaife S;Gray P;Labbé G;Beech C;Nimmo D;Alphey L;Vasan SS;Han Lim L;Wasi A N;Murad S
通讯作者：
Murad S
影响因子：
3.7
作者：
Alphey N;Alphey L;Bonsall MB
通讯作者：
Bonsall MB