The medial preoptic area is necessary for motivated choice of pup- over cocaine-associated environments by early postpartum rats.
The medial preoptic area is necessary for motivated choice of pup- over cocaine-associated environments by early postpartum rats.
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DOI：
10.1016/j.neuroscience.2010.02.015
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发表时间：
2010-05-05
期刊：
影响因子：
3.3
通讯作者：
Morrell, J. I.
中科院分区：
文献类型：
--
作者：
Pereira, M.;Morrell, J. I.
关键词：
汇聚的证据表明，在产后期间寻求可卡因的动机受到后代竞争激励的显着影响，这是这个生命阶段特有的刺激。在本研究中，内侧视前区（mPOA），一个关键的网站参与了母亲的反应，加工的奖励价值的小狗相关的线索和影响反应分配的可卡因相关的环境中的小狗/可卡因选择条件性位置偏好（CPP）的并行范式的功能作用进行了研究。产后早期的女性与双边引导插管旨在进入mPOA或进入解剖学控制网站的条件，产后（PPD）4至7天，将不同的独特的环境与幼崽或可卡因。在mPOA内输注2%布比卡因或盐水载体后，在PPD 8上测试CPP。在另外两个实验中，分别检查了布比卡因的mPOA内输注对由与幼仔或可卡因相关的环境诱导的条件反应的表达的影响。瞬时失活的mPOA选择性地阻断了条件偏好的小狗相关的环境，显着对比强大的小狗CPP中发现非手术和内mPOA车辆处理的女性。相比之下，mPOA失活未能改变产后女性的可卡因CPP。当在与幼犬或可卡因相关的环境之间做出选择时，mPOA的短暂功能失活改变了选择行为，使雌性对可卡因相关环境的偏好偏向，使得几乎所有的雌性都更喜欢可卡因-而不是与幼犬相关的选择。当mPOA相邻区域的失活不影响幼鼠的CPP反应时，揭示了解剖学特异性。研究结果支持的mPOA在调解小狗寻求行为的关键作用，并进一步表明，小狗的竞争性替代激励措施，包括滥用药物，依赖于mPOA的完整性，提供相关的小狗相关的信息，以电路的选择行为之间的小狗和替代刺激。
Converging evidence suggests that the motivation to seek cocaine during the postpartum period is significantly impacted by the competing incentives of offspring, a stimulus unique to this life stage. In the present study, the functional role of the medial preoptic area (mPOA), a critical site involved in maternal responsiveness, on processing incentive value of pup-associated cues and influencing response allocation for pup- over cocaine-associated environments was investigated using a concurrent pup/cocaine choice conditioned place preference (CPP) paradigm. Early postpartum females with bilateral guide cannulae aimed into the mPOA or into anatomical control sites were conditioned, from postpartum days (PPD) 4 to 7, to associate different uniquely featured environments with pups or cocaine. CPP was tested on PPD8 following intra-mPOA infusions of either 2% bupivacaine or saline vehicle. In two additional experiments, the effects of intra-mPOA infusions of bupivacaine on expression of conditioned responding induced by environments associated with either pups or cocaine were examined separately. Transient inactivation of the mPOA selectively blocked the conditioned preferences for pup-associated environments, significantly contrasting the robust pup-CPP found in non-surgical and intra-mPOA vehicle-treated females. In contrast, mPOA inactivation failed to alter cocaine-CPP in postpartum females. When given a choice between environments associated with pups or cocaine, transient functional inactivation of the mPOA altered choice behavior, biasing the preference of females toward cocaine-associated environments, such that almost all preferred cocaine- and none the pup-associated option. The anatomical specificity was revealed when inactivation of adjacent regions to the mPOA did not affect CPP responses for pups. The findings support a critical role for the mPOA in mediating pup-seeking behavior, and further suggest that the competing properties of pups over alternative incentives, including drugs of abuse, rely on mPOA integrity to provide relevant pup-related information to the circuitry underlying the choice behavior between pups and alternative stimuli.
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DOI：
10.1016/s0882-5963(98)80017-1
发表时间：
1998-10-01
期刊：
Journal of pediatric nursing
影响因子：
--
作者：
D'Apolito, K
通讯作者：
D'Apolito, K
影响因子：
3.3
作者：
De Vasconcelos, A. Pereira;Klur, S.;Cassel, J. C.
通讯作者：
Cassel, J. C.
DOI：
10.1080/14640748208400878
发表时间：
1982-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ADAMS, CD
通讯作者：
ADAMS, CD
影响因子：
2
作者：
Broadbent, NJ;Squire, LR;Clark, RE
通讯作者：
Clark, RE
影响因子：
2.9
作者：
FLEMING, AS;CHEUNG, U;KESSLER, Z
通讯作者：
KESSLER, Z