Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension.
Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension.
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产前高血压后焦虑、抑郁和学习障碍的证据。
DOI：
10.3390/bs12020053
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发表时间：
2022-02-18
期刊：
影响因子：
--
通讯作者：
Spencer SK
中科院分区：
文献类型：
--
作者：
Wallace K;Bowles T;Griffin A;Robinson R;Solis L;Railey T;Shaffery JP;Araji S;Spencer SK
背景资料：妊娠期高血压疾病，如先兆子痫（PreE）和HELLP（溶血，肝酶升高，血小板减少）综合征，影响约5-10%的妊娠，并增加妇女在产后期间发生疾病的风险，如焦虑或抑郁。使用临床前啮齿动物模型，我们着手确定是否有PreE或HELLP病史的大鼠有焦虑，抑郁或认知障碍的证据，以及怀孕期间的免疫抑制是否阻止了这些情绪和/或认知的变化。方法：从妊娠第12天开始，用sFlt-1和/或sEng分别诱导孕鼠PreE和HELLP。分娩后，一组经过验证的行为测定被用来评估产后抑郁症，焦虑和学习。结果如下：PreE或HELLP对母鼠与幼仔的相互作用没有负面影响;然而，高血压母鼠在强迫游泳试验中花费更多时间不动（p < 0.0001）。高血压母鼠在开放区域的开放区域花费的时间也更少（p = 0.001）。识别记忆无显著变化（p = 0.08）;然而，高血压母鼠的空间学习受损（p = 0.003）。强迫游泳试验中的不动时间与增加的循环S100 B呈正相关（p = 0.04），而在开放区域的外部区域花费的时间增加与BDNF水平呈负相关（p < 0.0001）。结论：本研究结果提示，妊娠期高血压疾病与产后抑郁、焦虑和学习障碍有关。
Background: Hypertensive disorders of pregnancy, such as Preeclampsia (PreE) and HELLP (hemolysis, elevated liver enzyme, low platelet) syndrome, affects approximately 5–10% of pregnancies and increases the risk of women developing disorders, such as anxiety or depression, in the postpartum period. Using preclinical rodent models, we set out to determine whether rats with a history of PreE or HELLP had evidence of anxiety, depression or cognitive impairment and whether immune suppression during pregnancy prevented these changes in mood and/or cognition. Methods: Timed-pregnant rats were infused with sFlt-1 and/or sEng to induce PreE or HELLP beginning on gestational day 12. After delivery, a battery of validated behavioral assays was used to assess post-partum depression, anxiety and learning. Results: There was no negative effect on maternal pup interaction due to PreE or HELLP; however, hypertensive dams spent more time immobile in the forced swim test (p < 0.0001). Hypertensive dams also spent less time in the open area of the open field (p = 0.001). There were no significant changes in recognition memory (p = 0.08); however, spatial learning was impaired in hypertensive dams (p = 0.003). Immobility time in the forced swim test was positively correlated with increased circulating S100B (p = 0.04), while increased time spent in the outer zones of the open field was negatively correlated with BDNF levels (p < 0.0001). Conclusion: The results from this study suggest that hypertensive pregnancy disorders are associated with depression, anxiety and learning impairments in the post-partum period.
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DOI：
10.1097/01.jom.0000100000.70011.bb
发表时间：
2003-12-01
影响因子：
3.2
作者：
Kessler, RC;Ormel, J;Stang, PE
通讯作者：
Stang, PE
影响因子：
6.6
作者：
Kikuchi, Saya;Murakami, Keiko;Tomita, Hiroaki
通讯作者：
Tomita, Hiroaki
影响因子：
9.8
作者：
Habli, Mounira;Eftekhari, Nahid;Sibai, Baha
通讯作者：
Sibai, Baha
影响因子：
9.8
作者：
Fields JA;Garovic VD;Mielke MM;Kantarci K;Jayachandran M;White WM;Butts AM;Graff-Radford J;Lahr BD;Bailey KR;Miller VM
通讯作者：
Miller VM
DOI：
10.1037/h0077579
发表时间：
1979-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BARNES, CA
通讯作者：
BARNES, CA