Heart disease risk factors in midlife predict subclinical coronary atherosclerosis more than 25 years later in survivors without clinical heart disease: the Rancho Bernardo Study.
Heart disease risk factors in midlife predict subclinical coronary atherosclerosis more than 25 years later in survivors without clinical heart disease: the Rancho Bernardo Study.
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DOI：
10.1111/j.1532-5415.2009.02268.x
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发表时间：
2009-06
影响因子：
6.3
通讯作者：
Kramer CK
中科院分区：
文献类型：
--
作者：
Barrett-Connor E;Bergstrom J;Wright M;Kramer CK
确定哪些典型的可改变的冠心病（CHD）危险因素，在中年测量，与老年亚临床冠状动脉粥样硬化相关。前瞻性研究以社区为基础的参与者是400名在社区居住的中年人，当测量冠心病危险因素时，他们在基线（1972-4年）没有冠心病史，并且在2000-2002年仍然没有已知的冠心病。2000-2002年采用计算机断层扫描冠状动脉钙化（CAC）评分评估冠状动脉斑块负荷。采用有序logistic回归分析比较基线危险因素与CAC严重程度。基线时的平均年龄为42岁，CAC评估时的平均年龄为69岁；46.5%为男性。在对年龄、性别和所有其他危险因素进行校正的分析中，体重指数[OR 1.24 (CI 95% 1.02-1.51) P = 0.03]、胆固醇[OR 1.28 (CI 95% 1.03-1.58) P = 0.02]、脉压[OR 1.24 (CI 95% 1.03-1.50) P = 0.03]和对数甘油三酯[OR1.22 (CI 95% 0.99-1.50 P = 0.06]的一个标准差增加分别独立预测冠状动脉粥样硬化的存在和严重程度。无临床心脏病的老年幸存者的斑块负担受25年前测量的可改变危险因素的影响。
To determine which of the classic modifiable coronary heart disease (CHD) risk factors, measured in midlife, are associated with subclinical coronary atherosclerosis in older age. Prospective study Community based Participants were 400 community-dwelling middle-aged adults who had no history of CHD at baseline (1972–4) when CHD risk factors were measured, and who were still free of known CHD in 2000–2002. Coronary artery plaque burden was assessed by coronary artery calcium (CAC) score using computed tomography in 2000–2002. Ordinal logistic regression analysis was used to compare baseline risk factors with severity of CAC. Mean age was 42 years at baseline and 69 years at the time of CAC assessment; 46.5% were male. In analyses adjusted for age, sex, and all other risk factors, one standard deviation increase in body mass index [OR 1.24 (CI 95% 1.02–1.51) P = 0.03], cholesterol [OR 1.28 (CI 95% 1.03–1.58) P = 0.02], pulse pressure [OR 1.24 (CI 95% 1.03–1.50) P = 0.03], and log triglycerides [OR1.22 (CI 95% 0.99–1.50 P = 0.06] each independently predicted the presence and severity of coronary artery atherosclerosis. Plaque burden in elderly survivors without clinical heart disease is influenced by modifiable risk factors measured more than 25 years earlier.
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影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB
影响因子：
8.9
作者：
Rumberger, JA;Sheedy, PF;Schwartz, RS
通讯作者：
Schwartz, RS
影响因子：
7.7
作者：
SEMENCIW, RM;MORRISON, HI;WIGLE, DT
通讯作者：
WIGLE, DT
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R
影响因子：
2.8
作者：
Guerci, AD;Spadaro, LA;Vizza, RF
通讯作者：
Vizza, RF