Prognostic significance of annexin II expression in non-small cell lung cancer
Prognostic significance of annexin II expression in non-small cell lung cancer
复制标题
膜联蛋白 II 表达在非小细胞肺癌中的预后意义
DOI：
10.1007/s12094-013-1028-y
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发表时间：
2013-03
影响因子：
3.4
通讯作者：
Liu Ying-Fu
中科院分区：
文献类型：
--
作者：
Luo Chun-Hua;Liu Qing-Qing;Zhang Peng-Fei;Li Mao-Yu;Chen Zhu-Chu;Liu Ying-Fu
目的探索两种非小细胞肺癌(NSCLC)类型肺鳞癌(LSC)和肺腺癌(AdC)中常见的转移相关和预后标志物。方法分别对LSC和AdC的原发癌组织和匹配的淋巴结转移组织进行定量蛋白质组学分析。采用免疫组织化学和统计分析来研究 LSC 和 AdC 中转移相关蛋白膜联蛋白 II 表达的预后意义。结果在 LSC 和 AdC 中，与相应的原发性肺癌相比，淋巴结转移性肺癌中膜联蛋白 II 的表达升高。此外，对大量临床标本的免疫组织化学分析表明，与相应的原发癌组织相比，在匹配的淋巴结转移组织中更频繁地观察到膜联蛋白 II 过度表达。统计分析显示，在两种亚型NSCLC中，annexin II过表达与晚期临床分期（P<0.05）和淋巴结转移（P<0.05）、复发率增加（P<0.05）和总生存率降低（P<0.05）显着相关。 Cox回归分析表明annexin II过表达是LSC和AdC的重要预后因素。结论Annexin II被认为是LSC和AdC的常见预后因素。
PurposeTo discover common metastasis-related and prognostic markers in lung squamous carcinoma (LSC) and lung adenocarcinoma (AdC), two forms of non-small cell lung cancer (NSCLC).MethodsQuantitative proteomic analysis was performed between primary cancer tissues and matched lymph node metastatic tissues in LSC and AdC, respectively. Immunohistochemistry and statistic analysis were performed to investigate prognostic significance of metastasis-related protein annexin II expression in LSC and AdC.ResultsBoth in LSC and AdC, elevated expression of annexin II was identified in lymph node metastatic lung cancers compared to corresponding primary lung cancers. Furthermore, immunohistochemical analysis of a bulk of clinical specimens indicated that annexin II over-expression was more frequently observed in matched lymph node metastatic tissues than corresponding primary cancer tissues. Statistical analysis showed that annexin II over-expression was significantly associated with advanced clinical stage (P< 0.05) and lymph node metastasis (P< 0.05) and increased relapse rate (P< 0.05) and decreased overall survival (P< 0.05) in both two subtypes of NSCLC. Cox regression analysis indicated that annexin II over-expression was an important prognostic factor in both LSC and AdC.ConclusionAnnexin II was identified as a common prognostic factor in both LSC and AdC.
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影响因子：
8.8
作者：
通讯作者：
--
在多药抗性小细胞肺癌细胞系中，膜联蛋白II（Lipocortin II，p36）的表达升高。
影响因子：
8.8
作者：
Cole, S P;Pinkoski, M J;Bhardwaj, G;Deeley, R G
通讯作者：
Deeley, R G
影响因子：
3.7
作者：
Sakwe AM;Koumangoye R;Guillory B;Ochieng J
通讯作者：
Ochieng J
影响因子：
11.5
作者：
Cheng, Ai-Lan;Huang, Wei-Guo;Xiao, Zhi-Qiang
通讯作者：
Xiao, Zhi-Qiang
影响因子：
4.7
作者：
J. Vishwanatha;Y. Chiang;K. Kumble;K. Kumble;M. Hollingsworth;P. Pour
通讯作者：
J. Vishwanatha;Y. Chiang;K. Kumble;K. Kumble;M. Hollingsworth;P. Pour