Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons.
Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons.
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DOI：
10.1111/j.1447-0594.2010.00668.x
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发表时间：
2011-04
影响因子：
3.3
通讯作者：
Pahor M
中科院分区：
文献类型：
--
作者：
Cesari M;Incalzi RA;Zamboni V;Pahor M
维生素D是一种促性腺激素，传统上被认为是骨代谢的关键调节剂，通过与甲状旁腺激素的负反馈调节钙和磷的稳态。然而，在过去的二十年里，维生素D所扮演的角色已经被很大程度上修改了，认识到它对广泛的系统、器官和组织具有多效性作用。因此，维生素D被越来越多地作为生物修饰和特定临床条件的主要决定因素。在全球老龄化的背景下，维生素D对骨骼肌和相关结果(包括身体功能下降和残疾)的影响肯定是最相关的研究之一。在本综述中，描述了维生素D缺乏/不足的亚临床和临床后果，维生素D缺乏/不足是老年人中非常常见的情况。特别关注骨骼肌和身体功能。对现有科学证据的局限性也进行了讨论。
Vitamin D, a secosteroid (pro)-hormone, has been traditionally considered as a key regulator of bone metabolism, and calcium and phosphorous homeostasis through a negative feedback with the parathyroid hormone. However, during the last twenty years, the role played by vitamin D has been largely revised by recognizing it a pleiotropic action on a wide spectrum of systems, apparati, and tissues. Thus, vitamin D has growingly been involved as a primary determinant of biological modifications and specific clinical conditions. The effect of vitamin D on skeletal muscle and related outcomes (including physical function decline and disability) is surely one of the most relevant to study in the context of global aging. In the present review, the subclinical and clinical consequences of vitamin D deficiency/insufficiency, extremely frequent conditions in older age, are described. Special focus is given to skeletal muscle and physical function. Limitations of available scientific evidence on the topic are also discussed.
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影响因子：
6.2
作者：
Bischoff, HA;Stähelin, HB;Conzelmann, M
通讯作者：
Conzelmann, M
DOI：
10.1111/j.1532-5415.2007.01048.x
发表时间：
2007-02-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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