Thymosin β4 mobilizes mesothelial cells for blood vessel repair.
Thymosin β4 mobilizes mesothelial cells for blood vessel repair.
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DOI：
10.1111/j.1749-6632.2012.06713.x
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发表时间：
2012-10
影响因子：
5.2
通讯作者：
Bader DM
中科院分区：
文献类型：
--
作者：
Shelton EL;Bader DM
间皮是覆盖所有腹部器官和这些器官所在体腔的简单鳞状上皮。虽然这种细胞类型的结构特征在一个世纪前就已被记录，但其在发育、疾病和伤口愈合方面的潜力直到现在才变得明显。在胚胎中，间皮为发育中的心脏、肺和肠道提供血管生成细胞。此外，可以使用胸腺肽 β4 重新激活成体间皮细胞并动员其帮助组织修复。尽管间皮在发育和修复中发挥积极作用，但也容易发生粘附和肿瘤形成。了解间皮是组织修复和疾病的重要介质后，确定能够增强这些细胞能力的其他因子（如胸腺肽 β4）就变得很重要。未来化学和遗传制剂与间皮细胞的结合使用将增强治疗潜力并减轻有害结果。
Mesothelium is the simple squamous epithelium covering all abdominal organs and the coeloms in which those organs reside. While the structural characteristics of this cell type were documented a century ago, its potential in development, disease, and wound healing is only now becoming apparent. In the embryo, mesothelia provide vasculogenic cells for the developing heart, lungs, and gut. Furthermore, adult mesothelial cells can be reactivated using Thymosin β4 and mobilized to aid in tissue repair. Despite their positive role in development and repair, mesothelia are also susceptible to adhesion and tumor formation. With knowledge that the mesothelium is an important mediator of tissue repair as well as disease, it will be important to identify other factors like Thymosin β4 that have the ability to potentiate these cells. Future use of chemical and genetic agents in conjunction with mesothelial cells will lead to enhanced therapeutic potential and mitigation of deleterious outcomes.
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DOI：
10.1196/annals.1415.049
发表时间：
2007-01-01
期刊：
THYMOSINS IN HEALTH AND DISEASE: FIRST INTERNATIONAL SYMPOSIUM
影响因子：
--
作者：
Godschalk, Michael Francis
通讯作者：
Godschalk, Michael Francis
胸腺素 beta4 介导的 PKC 激活对于成年小鼠体内启动胚胎冠状动脉发育程序和心外膜祖细胞激活至关重要。
影响因子：
5
作者：
Bock-Marquette, Ildiko;Shrivastava, Santwana;Pipes, G. C. Teg;Thatcher, Jeffrey E.;Blystone, Allissa;Shelton, John M.;Galindo, Cristi L.;Melegh, Bela;Srivastava, Deepak;Olson, Eric N.;DiMaio, J. Michael
通讯作者：
DiMaio, J. Michael
影响因子：
37.8
作者：
Hinkel, Rabea;El-Aouni, Chiraz;Kupatt, Christian
通讯作者：
Kupatt, Christian
影响因子：
2.7
作者：
Mikawa, T;Gourdie, RG
通讯作者：
Gourdie, RG
影响因子：
3
作者：
CANNADAY, JE
通讯作者：
CANNADAY, JE