Age- and sex-related variations in the brain white matter fractal dimension throughout adulthood: an MRI study.
Age- and sex-related variations in the brain white matter fractal dimension throughout adulthood: an MRI study.
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DOI：
10.1007/s00062-013-0273-3
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发表时间：
2015-03
影响因子：
2.8
通讯作者：
Ashburner, J.
中科院分区：
文献类型：
--
作者：
Farahibozorg, S.;Hashemi-Golpayegani, S. M.;Ashburner, J.
通过分形维(FD)观察成年期大脑半球和大脑半球白质(WM)复杂性的年龄和性别差异。使用盒数算法从209例健康成人的WM磁共振图像中提取FD，包括一般(GFD)、骨骼(SFD)和边界(BFD)三个结构层。模型选择算法和统计分析分别用于检查变化的模式和意义。GFD和SFD随年龄增长呈倒U形变化，从青年到中年的上升幅度较小，到老年的下降幅度较大。BFD受年龄影响较小。性别差异明显，特别是在GFD和SFD，男性表现出更高的FDD。年龄×性别的交互作用主要在半球分析中显著，男性经历了更剧烈的年龄相关变化。在对音量效应进行调整后，与年龄相关的结果大致相同，但大多数特征的性别差异发生了变化，女性表现出更高的值，特别是在左半球和边界。男性右脑的情况更为复杂。这项研究首次将年龄作为一个连续变量和分类变量来研究成年后的WM FD。我们发现FD与体积呈正相关，我们的结果与那些研究大脑网络的小世界属性以及功能复杂性和WM完整性的结果相似。这些表明，FD可以高度紧凑地描述结构变化，也可能向我们提供有关功能和认知变化的信息。
To observe age- and sex-related differences in the complexity of the global and hemispheric white matter (WM) throughout adulthood by means of fractal dimension (FD). A box-counting algorithm was used to extract FD from the WM magnetic resonance images of 209 healthy adults from three structural layers, including general (gFD), skeleton (sFD), and boundaries (bFD). Model selection algorithms and statistical analyses, respectively, were used to examine the patterns and significance of the changes. gFD and sFD showed inverse U-shape patterns with aging, with a slighter slope of increase from young to mid-age and a steeper decrease to the old. bFD was less affected by age. Sex differences were evident, specifically in gFD and sFD, with men showing higher FDs. Age × sex interaction was significant mainly in the hemispheric analysis, with men undergoing sharper age-related changes. After adjusting for the volume effect, age-related results remained approximately the same, but sex differences changed in most of the features, with women indicating higher values, specifically in the left hemisphere and boundaries. Right hemisphere was still more complex in men. This study is the first that investigates the WM FD spanning adulthood, treating age both as a continuous and categorical variable. We found positive correlations between FD and volume, and our results show similarities with those investigating small-world properties of the brain networks, as well as those of functional complexity and WM integrity. These suggest that FD could yield a highly compact description of the structural changes and also might inform us about functional and cognitive variations.
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影响因子：
2.5
作者：
Ahmadi, Khodabakhsh;Ahmadlou, Mehran;Sajedi, Firoozeh
通讯作者：
Sajedi, Firoozeh
影响因子：
5.7
作者：
Lemaître, H;Crivello, F;Mazoyer, B
通讯作者：
Mazoyer, B
影响因子：
5.7
作者：
Fernandez, Alberto;Rios-Lago, Marcos;Ortiz, Tomas
通讯作者：
Ortiz, Tomas
影响因子：
56.9
作者：
MANDELBROT, B
通讯作者：
MANDELBROT, B
DOI：
10.1073/pnas.1117943109
发表时间：
2012-10-09
影响因子：
11.1
作者：
Miller, Daniel J.;Duka, Tetyana;Sherwood, Chet C.
通讯作者：
Sherwood, Chet C.