Saliva: physiology and diagnostic potential in health and disease.

Saliva: physiology and diagnostic potential in health and disease.
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DOI:
10.1100/tsw.2010.38
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发表时间:
2010-03-16
影响因子:
--
通讯作者:
Renshaw D
Renshaw D
中科院分区:
其他
文献类型:
--
作者:
Farnaud SJ;Kosti O;Getting SJ;Renshaw D

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唾液被描述为身体的镜子。在一个医疗成本飙升的世界和一个快速诊断可能对患者的积极结果至关重要的环境中,唾液正在成为血液采样的可行替代方案。本文综述了口腔唾液的组成及其在口腔软组织保护、抗菌活性和口腔组织修复等方面的生理作用。然后我们探索唾液作为局部口腔疾病的诊断标志物,并特别关注口腔癌。当我们关注通过唾液生物标志物进行全体性疾病诊断时,癌症主题仍在继续。传染病是下一节的重点,在这里我们回顾有关从人类唾液直接和间接检测致病性感染的文献。最后,我们讨论了参与食欲调节的激素,以及唾液是否可以替代血液来监测与饱腹感有关的激素。
Saliva has been described as the mirror of the body. In a world of soaring healthcare costs and an environment where rapid diagnosis may be critical to a positive patient outcome, saliva is emerging as a viable alternative to blood sampling. In this review, we discuss the composition and various physiological roles of saliva in the oral cavity, including soft tissue protection, antimicrobial activities, and oral tissue repair. We then explore saliva as a diagnostic marker of local oral disease and focus particularly on oral cancers. The cancer theme continues when we focus on systemic disease diagnosis from salivary biomarkers. Communicable disease is the focus of the next section where we review the literature relating to the direct and indirect detection of pathogenic infections from human saliva. Finally, we discuss hormones involved in appetite regulation and whether saliva is a viable alternative to blood in order to monitor hormones that are involved in satiety.
DOI: 10.1080/080352501750315663
发表时间: 2001-07-01
期刊: ACTA PAEDIATRICA
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