Targeted Microbubbles for Drug, Gene, and Cell Delivery in Therapy and Immunotherapy.
Targeted Microbubbles for Drug, Gene, and Cell Delivery in Therapy and Immunotherapy.
复制标题
DOI：
10.3390/pharmaceutics15061625
复制
发表时间：
2023-05-30
期刊：
影响因子：
5.4
通讯作者：
Borden MA
中科院分区：
文献类型：
--
作者：
Navarro-Becerra JA;Borden MA
微泡是直径为1-10 μm的充气声活性颗粒，通常由磷脂单层壳稳定。微泡可以通过配体、药物和/或细胞的生物缀合来工程化。自几十年前问世以来，已经开发了几种靶向微泡（tMB）制剂作为超声成像探针和超声响应载体，以促进各种药物、基因和细胞在不同治疗应用中的局部递送和摄取。本综述的目的是总结当前tMB制剂及其超声靶向递送应用的最新进展。我们提供了一个概述不同的载体，用于增加药物负载能力和不同的靶向策略，可用于增强局部输送，增强疗效，并尽量减少副作用。此外，提出了未来的方向，以提高诊断和治疗应用中的tMB性能。
Microbubbles are 1–10 μm diameter gas-filled acoustically-active particles, typically stabilized by a phospholipid monolayer shell. Microbubbles can be engineered through bioconjugation of a ligand, drug and/or cell. Since their inception a few decades ago, several targeted microbubble (tMB) formulations have been developed as ultrasound imaging probes and ultrasound-responsive carriers to promote the local delivery and uptake of a wide variety of drugs, genes, and cells in different therapeutic applications. The aim of this review is to summarize the state-of-the-art of current tMB formulations and their ultrasound-targeted delivery applications. We provide an overview of different carriers used to increase drug loading capacity and different targeting strategies that can be used to enhance local delivery, potentiate therapeutic efficacy, and minimize side effects. Additionally, future directions are proposed to improve the tMB performance in diagnostic and therapeutic applications.
登录
查看更多内容
影响因子：
2.9
作者：
Angel Navarro-Becerra, J.;Franco-Urquijo, Carlos A.;Escalante, Bruno
通讯作者：
Escalante, Bruno
影响因子：
2.9
作者：
Gessner, Ryan C.;Streeter, Jason E.;Kothadia, Roshni;Feingold, Steven;Dayton, Paul A.
通讯作者：
Dayton, Paul A.
DOI：
10.3390/nano11020415
发表时间：
2021-02-06
期刊：
Nanomaterials (Basel, Switzerland)
影响因子：
--
作者：
Barmin RA;Rudakovskaya PG;Gusliakova OI;Sindeeva OA;Prikhozhdenko ES;Maksimova EA;Obukhova EN;Chernyshev VS;Khlebtsov BN;Solovev AA;Sukhorukov GB;Gorin DA
通讯作者：
Gorin DA
影响因子：
2.9
作者：
Chatterjee, D;Sarkar, K
通讯作者：
Sarkar, K
影响因子：
10.8
作者：
Chang, En-Ling;Ting, Chien-Yu;Yeh, Chih-Kuang
通讯作者：
Yeh, Chih-Kuang