An in vivo validation of the application of acoustic radiation force to enhance the diagnostic utility of molecular imaging using 3-d ultrasound.
An in vivo validation of the application of acoustic radiation force to enhance the diagnostic utility of molecular imaging using 3-d ultrasound.
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DOI：
10.1016/j.ultrasmedbio.2011.12.005
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发表时间：
2012-04
影响因子：
2.9
通讯作者：
Dayton, Paul A.
中科院分区：
文献类型：
--
作者：
Gessner, Ryan C.;Streeter, Jason E.;Kothadia, Roshni;Feingold, Steven;Dayton, Paul A.
十多年来，声辐射力（ARF）的应用已被提出作为一种机制，以提高超声分子成像（MI）的灵敏度在体内。本文介绍的是第一个非侵入性体内验证急性肾衰增强心肌梗死与未经修改的临床系统。首先，使用体外光声设置来优化系统参数，并确保暴露于ARF时有足够的微泡平移。然后使用靶向αvβ3的微泡和非靶向微泡对7个大鼠纤维肉瘤肿瘤进行3D ARF增强MI。对低振幅（< 25 kPa）3D ARF脉冲序列进行了测试，并与同一动物的被动靶向研究进行了比较。我们的研究结果表明，当使用ARF相对于被动靶向研究时，靶向微泡的图像强度可增加78%。此外，当应用于非靶向药物时，ARF没有显著增加图像对比度，表明ARF没有增加非特异性粘附。
For over a decade, the application of acoustic radiation force (ARF) has been proposed as a mechanism to increase ultrasonic molecular imaging (MI) sensitivity in vivo. Presented herein is the first noninvasive in vivo validation of ARF-enhanced MI with an unmodified clinical system. First, an in vitro optical-acoustical setup was used to optimize system parameters and ensure sufficient microbubble translation when exposed to ARF. 3D ARF-enhanced MI was then performed on 7 rat fibrosarcoma tumors using microbubbles targeted to αvβ3 and non-targeted microbubbles. Low-amplitude (< 25 kPa) 3D ARF pulse sequences were tested and compared to passive targeting studies in the same animal. Our results demonstrate that a 78% increase in image intensity from targeted microbubbles can be achieved when using ARF relative to the passive targeting studies. Furthermore, ARF did not significantly increase image contrast when applied to non-targeted agents, suggesting that ARF did not increase non-specific adhesion.
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影响因子：
2.9
作者：
Patil, Abhay V.;Rychak, Joshua J.;Allen, John S.;Klibanov, Alexander L.;Hossack, John A.
通讯作者：
Hossack, John A.
影响因子：
11.2
作者：
Palmowski, Moritz;Huppert, Jochen;Kiessling, Fabian
通讯作者：
Kiessling, Fabian
DOI：
10.1109/tuffc.2004.1320741
发表时间：
2004-07-01
影响因子：
3.6
作者：
Shortencarier, MJ;Dayton, PA;Ferrara, KW
通讯作者：
Ferrara, KW
DOI：
10.1109/tuffc.2005.1417264
发表时间：
2005-03-01
影响因子：
3.6
作者：
Rychak, JJ;Klibanov, AL;Hossack, JA
通讯作者：
Hossack, JA
影响因子：
2.9
作者：
Rychak, Joshua J.;Klibanov, Alexander L.;Hossack, John A.
通讯作者：
Hossack, John A.