Interleukin-6: discovery of a pleiotropic cytokine.
Interleukin-6: discovery of a pleiotropic cytokine.
复制标题
DOI：
10.1186/ar1916
复制
发表时间：
2006
影响因子：
4.9
通讯作者：
Kishimoto T
中科院分区：
文献类型：
--
作者：
Kishimoto T
20世纪60年代末，T细胞在抗体产生中所起的重要作用被报道。这导致了我们的假设，即某些分子必须从T细胞中释放出来，才能刺激B细胞。这一假设被证明是正确的。T细胞培养上清液中存在一定的诱导B细胞增殖和分化的因子。诱导B细胞产生免疫球蛋白的因子最初被命名为B细胞刺激因子-2。人B细胞刺激因子-2的编码区于1986年被克隆。同时，在成纤维细胞中独立克隆了干扰素-β-2和一个26 kDa的蛋白，发现其与B细胞刺激因子-2相同。后来，杂交瘤/浆细胞瘤生长因子和肝细胞刺激因子也被证明是与B细胞刺激因子-2相同的分子。由于具有多种生物学活性，人们对这种单一分子使用了不同的名称，但这些名称都被统一了，这种分子现在被称为IL-6。自从IL-6被发现以来，我们对IL-6活性、IL-6受体系统和IL-6信号转导机制的认识都取得了很大的进展。更重要的是，它已被证明与许多疾病有关，如类风湿性关节炎和卡斯特尔曼病。考虑到对该分子各个方面积累的基础研究，阻断IL-6的活性似乎是治疗慢性炎症性疾病的一种可行的新方法。
In the late 1960s, the essential role played by T cells in antibody production was reported. This led to our hypothesis that certain molecules would have to be released from T cells to effect the stimulation of B cells. This hypothesis was shown to be true. There were certain factors present in the culture supernatant of T cells that induced proliferation and differentiation of B cells. The factor that induced B cells to produce immunoglobulins was initially named B cell stimulatory factor-2. The cDNA encoding the human B cell stimulatory factor-2 was cloned in 1986. At the same time, IFN-β2 and a 26 kDa protein in the fibroblasts were independently cloned and found to be identical to B cell stimulatory factor-2. Later, a hybridoma/plasmacytoma growth factor and a hepatocyte stimulating factor were also proven to be the same molecule as B cell stimulatory factor-2. Various names were used for this single molecule because of its multiple biological activities, but these have all been unified and the molecule is now known as IL-6. Since the discovery of IL-6, rapid progress has been made in our understanding of IL-6 activities, the IL-6 receptor system and the IL-6 signal transduction mechanism. More importantly, it has been shown to be involved in a number of diseases such as rheumatoid arthritis and Castleman's disease. When taking into account all the accumulated basic research on the various aspects of this molecule, it appeared that blocking the activity of IL-6 was a feasible, new therapeutic approach for chronic inflammatory diseases.
登录
查看更多内容
DOI：
10.1073/pnas.84.1.228
发表时间：
1987-01-01
影响因子：
11.1
作者：
HIRANO, T;TAGA, T;KISHIMOTO, T
通讯作者：
KISHIMOTO, T
影响因子：
64.8
作者：
HIRANO, T;YASUKAWA, K;KISHIMOTO, T
通讯作者：
KISHIMOTO, T
影响因子：
6.1
作者：
Hirata, M;Endo, K;Fukagawa, M
通讯作者：
Fukagawa, M
影响因子：
4.8
作者：
Franchimont, N;Rydziel, S;Canalis, E
通讯作者：
Canalis, E
影响因子：
4.4
作者：
De Benedetti, F;Pignatti, P;Martini, A
通讯作者：
Martini, A