SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors.
SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors.
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DOI：
10.1016/j.lungcan.2012.02.017
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Yang P
中科院分区：
文献类型：
--
作者：
Rausch SM;Gonzalez BD;Clark MM;Patten C;Felten S;Liu H;Li Y;Sloan J;Yang P
与其他癌症幸存者相比，肺癌幸存者的生活质量最低。疼痛是肺癌幸存者最具破坏性，持续性和失能性的症状之一。患病率各不相同，80-100%的幸存者经历过癌症疼痛，而疼痛不受控制的癌症幸存者的医疗费用高出5倍。癌症疼痛通常对癌症患者和癌症幸存者的生活质量有相当大的影响。因此，早期识别和治疗非常重要。虽然最近的研究表明，在几个细胞因子和炎症基因的单核苷酸多态性（SNP）与癌症预后之间的关系，与癌症疼痛的关联尚不清楚。因此，本研究的主要目的是确定与长期肺癌幸存者疼痛相关的SNP。参与者在诊断为肺癌后被纳入马约诊所肺癌队列。1149名白人肺癌幸存者（440名存活< 3年; 354名存活3-5年; 355名存活> 5年）完成了研究问卷并获得了遗传样本。基于血清文献，从PTGS 2和LTA基因中选择10个SNPS。结局包括疼痛和SF-8测量的生活质量。在LTA和PTGS 2基因中评估的10个SNP中，3个与疼痛严重程度（rs 5277; rs 1799964）、社会功能（rs 5277）和心理健康（rs 5275）相关。这些结果表明这些炎症基因SNP在预测长期肺癌幸存者疼痛严重程度方面的特异性和一致性。这些结果为疼痛严重程度的遗传易感性提供了支持，并可能有助于确定肺癌幸存者的发病率和生活质量差的高风险。
Lung cancer survivors report the lowest quality of life relative to other cancer survivors. Pain is one of the most devastating, persistent, and incapacitating symptoms for lung cancer survivors. Prevalence rates vary with 80–100% of survivors experiencing cancer pain and healthcare costs are five times higher in cancer survivors with uncontrolled pain. Cancer pain often has a considerable impact on quality of life among cancer patients and cancer survivors. Therefore, early identification, and treatment is important. Although recent studies have suggested a relationship between single nucleotide polymorphisms (SNPs) in several cytokine and inflammation genes with cancer prognosis, associations with cancer pain are not clear. Therefore, the primary aim of this study was to identify SNPs related to pain in long term lung cancer survivors. Participants were enrolled in the Mayo Clinic Lung Cancer Cohort upon diagnosis of their lung cancer. 1149 Caucasian lung cancer survivors, (440 surviving < 3 years; 354 surviving 3–5 years; and 355 surviving> 5 years) completed study questionnaires and had genetic samples available. Ten SNPS from PTGS2 and LTA genes were selected based on the serum literature. Outcomes included pain, and quality of life as measured by the SF-8. Of the 10 SNPs evaluated in LTA and PTGS2 genes, 3 were associated with pain severity (rs5277; rs1799964), social function (rs5277) and mental health (rs5275). These results suggested both specificity and consistency of these inflammatory gene SNPs in predicting pain severity in long term lung cancer survivors. These results provide support for genetic predisposition to pain severity and may aid in identification of lung cancer survivors at high risk for morbidity and poor QOL.
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DOI：
10.1016/j.ijrobp.2004.12.027
发表时间：
2005-07-15
影响因子：
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作者：
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发表时间：
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影响因子：
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作者：
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影响因子：
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