Relationship between regional gray matter volumes and dopamine D(2) receptor and transporter in living human brains.
Relationship between regional gray matter volumes and dopamine D(2) receptor and transporter in living human brains.
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DOI：
10.1002/hbm.25538
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发表时间：
2021-08-15
影响因子：
4.8
通讯作者：
Higuchi M
中科院分区：
文献类型：
--
作者：
Kurose S;Kubota M;Takahata K;Yamamoto Y;Fujiwara H;Kimura Y;Ito H;Takeuchi H;Mimura M;Suhara T;Higuchi M
虽然纹状体多巴胺神经传递被认为与皮质纹状体网络的形成有功能联系，但很少有证据表明人脑中的这种调节过程及其在神经精神疾病中的破坏。在这里，我们的目的是调查纹状体多巴胺转运蛋白（DAT）和D2受体的可用性与健康人的灰质（GM）体积的关联。在我们之前的研究中，分别采集了用特定放射性配体[11 C]雷氯必利和[18 F]FE‐ PE 2 I捕获的D2受体（n = 34）和DAT（n = 17）的正电子发射断层扫描图像沿着T1加权磁共振成像数据，并在本研究中进行了重新分析。我们量化了这些放射性配体在纹状体边缘系统，执行和感觉运动功能亚区的结合潜力（BP ND）。然后通过基于体素的形态测定法检查放射性配体BP ND和局部GM体积之间的相关性。与功能和解剖学连接一致，边缘纹状体中的[11 C]雷氯必利BP ND与钩回/海马旁回和邻近颞区的体积呈正相关。同样，我们发现BP ND的这种放射性配体在执行纹状体和体积的前额叶皮质及其邻近地区之间的正相关性，以及BP ND在感觉运动纹状体和体积的躯体感觉和辅助运动区。相比之下，在[18F] FE-PE 2 I BP ND和区域GM体积之间未发现显著相关性。我们的研究结果表明，在健康人中，涉及D2受体的皮质纹状体独特的结构和功能关联，这可能部分独立于纹状体DAT所反映的黑质纹状体通路。这是第一个研究健康成年人纹状体中区域灰质体积与多巴胺D2受体和转运蛋白的可用性之间的关系的研究，通过使用我们以前的磁共振成像和正电子发射断层扫描数据集。我们已经证明了多巴胺D2/3受体放射性配体BP ND在纹状体的功能亚区和灰质（GM）体积的区域，可以在功能和解剖学上连接到每个这些纹状体子域之间的正相关性。同时，多巴胺转运体放射性配体BP ND与区域GM体积之间未观察到显著相关性。
Although striatal dopamine neurotransmission is believed to be functionally linked to the formation of the corticostriatal network, there has been little evidence for this regulatory process in the human brain and its disruptions in neuropsychiatric disorders. Here, we aimed to investigate associations of striatal dopamine transporter (DAT) and D2 receptor availabilities with gray matter (GM) volumes in healthy humans. Positron emission tomography images of D2 receptor (n = 34) and DAT (n = 17) captured with the specific radioligands [11C]raclopride and [18F]FE‐PE2I, respectively, were acquired along with T1‐weighted magnetic resonance imaging data in our previous studies, and were re‐analyzed in this work. We quantified the binding potentials (BP ND) of these radioligands in the limbic, executive, and sensorimotor functional subregions of the striatum. Correlations between the radioligand BP ND and regional GM volume were then examined by voxel‐based morphometry. In line with the functional and anatomical connectivity, [11C]raclopride BP ND in the limbic striatum was positively correlated with volumes of the uncal/parahippocampal gyrus and adjacent temporal areas. Similarly, we found positive correlations between the BP ND of this radioligand in the executive striatum and volumes of the prefrontal cortices and their adjacent areas as well as between the BP ND in the sensorimotor striatum and volumes of the somatosensory and supplementary motor areas. By contrast, no significant correlation was found between [18F]FE‐PE2I BP ND and regional GM volumes. Our results suggest unique structural and functional corticostriatal associations involving D2 receptor in healthy humans, which might be partially independent of the nigrostriatal pathway reflected by striatal DAT. This is the first study to investigate the relationship between regional gray matter volumes and availabilities of both dopamine D2 receptor and transporter in the striatum of healthy adults, by using our previous magnetic resonance imaging and positron emission tomography datasets. We have demonstrated positive correlations between dopamine D2/3 receptor radioligand BP ND in the functional subregions of the striatum and the gray matter (GM) volumes of regions that could be functionally and anatomically connected to each of these striatal subdomains. Meanwhile, no marked correlations were observed between dopamine transporter radioligand BP ND and regional GM volumes.
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影响因子：
6.3
作者：
Alakurtti, Kati;Johansson, Jarkko J.;Rinne, Juha O.
通讯作者：
Rinne, Juha O.
影响因子：
6
作者：
Boileau, Isabelle;Payer, Doris;Zack, Martin
通讯作者：
Zack, Martin
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender
影响因子：
2.5
作者：
CASS, WA;GERHARDT, GA
通讯作者：
GERHARDT, GA
影响因子：
2.6
作者：
Borich MR;Brodie SM;Gray WA;Ionta S;Boyd LA
通讯作者：
Boyd LA