The gut-meningeal immune axis: Priming brain defense against the most likely invaders.
The gut-meningeal immune axis: Priming brain defense against the most likely invaders.
复制标题
肠-脑膜免疫轴：启动大脑防御最可能的入侵者。
DOI：
10.1084/jem.20211520
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发表时间：
2022-03-07
期刊：
影响因子：
--
通讯作者：
Clatworthy MR
中科院分区：
文献类型：
--
作者：
Di Marco Barros R;Fitzpatrick Z;Clatworthy MR
脑膜的血管系统含有有窗口的内皮细胞，使其容易受到循环微生物的入侵，这些微生物通常来自肠道。在这里，我们讨论肠道和脑膜免疫之间的密切联系如何使中枢神经系统防御血液传播的入侵者。胃肠道含有数以万亿计的微生物，由于具有耐受性、富含调节细胞的肠道免疫系统，这些微生物与宿主共生。然而，这种与微生物的亲密关系不可避免地伴随着风险，肠道微生物是菌血症最常见的原因。脑膜的血管系统含有有窗口的内皮细胞，使其容易受到循环中微生物的入侵。我们认为，这在进化上导致了肠道和脑膜免疫之间的密切联系，以增强中枢神经系统对最可能的入侵者的防御。硬脑膜静脉窦免疫球蛋白A防御系统就是这种模式的例证，它的抗体库反映了肠道的抗体库。
The vasculature of the meninges contains fenestrated endothelium conferring vulnerability to invasion by circulating microbes, often arising from the gut. Here, we discuss how close links between intestinal and meningeal immunity enable central nervous system defense against blood-borne invaders. The gastrointestinal tract contains trillions of microorganisms that exist symbiotically with the host due to a tolerant, regulatory cell–rich intestinal immune system. However, this intimate relationship with the microbiome inevitably comes with risks, with intestinal organisms being the most common cause of bacteremia. The vasculature of the brain-lining meninges contains fenestrated endothelium, conferring vulnerability to invasion by circulating microbes. We propose that this has evolutionarily led to close links between gut and meningeal immunity, to prime the central nervous system defense against the most likely invaders. This paradigm is exemplified by the dural venous sinus IgA defense system, where the antibody repertoire mirrors that of the gut.
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影响因子：
82.9
作者：
Benakis C;Brea D;Caballero S;Faraco G;Moore J;Murphy M;Sita G;Racchumi G;Ling L;Pamer EG;Iadecola C;Anrather J
通讯作者：
Anrather J
影响因子：
4.7
作者：
Breit S;Kupferberg A;Rogler G;Hasler G
通讯作者：
Hasler G
影响因子：
64.8
作者：
Ahn, Ji Hoon;Cho, Hyunsoo;Koh, Gou Young
通讯作者：
Koh, Gou Young
影响因子：
17.1
作者：
Iliff JJ;Wang M;Liao Y;Plogg BA;Peng W;Gundersen GA;Benveniste H;Vates GE;Deane R;Goldman SA;Nagelhus EA;Nedergaard M
通讯作者：
Nedergaard M
DOI：
10.1126/science.abf9277
发表时间：
2021-07-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Brioschi S;Wang WL;Peng V;Wang M;Shchukina I;Greenberg ZJ;Bando JK;Jaeger N;Czepielewski RS;Swain A;Mogilenko DA;Beatty WL;Bayguinov P;Fitzpatrick JAJ;Schuettpelz LG;Fronick CC;Smirnov I;Kipnis J;Shapiro VS;Wu GF;Gilfillan S;Cella M;Artyomov MN;Kleinstein SH;Colonna M
通讯作者：
Colonna M