Interactive effects of molecular subtypes with tumor size and extracranial metastatic pattern on risk of brain metastasis in breast cancer patients: A population-based study.
Interactive effects of molecular subtypes with tumor size and extracranial metastatic pattern on risk of brain metastasis in breast cancer patients: A population-based study.
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DOI：
10.1002/cam4.5425
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发表时间：
2023-03
期刊：
影响因子：
4
通讯作者：
Wang, Kun
中科院分区：
文献类型：
--
作者：
Shen, Bo;Li, Jieqing;Yang, Mei;Liu, Kangkang;Zhang, Junsheng;Li, Weiping;Zhang, Yi;Wang, Kun
关键词：
早期检测脑转移（BM）对于改善乳腺癌（BC）患者的预后至关重要。目的是在人群水平上确定不同分子亚型的 BCBM 预测因子。利用监测、流行病学和最终结果数据库选择 2010 年至 2018 年诊断的 BC 患者。我们评估了 BCBM 的发病率和危险因素，并测试了分子亚型与其他危险因素之间的相互作用。在 527,525 名选定的患者中，在排除关键因素状态未知的患者后，分子亚型与 T 分期和颅外转移 (ECM) 模式对整个 BC 人群的 BM 风险显着相互作用（相互作用 p = 0.002，<0.001）。仅在 HR−/HER2− 患者中，BM 发育与 T 分期无关（趋势 p = 0.126）。我们选择了具有单器官 ECM 的 BC 患者，发现分子亚型和 ECM 模式之间存在显着的相互作用（相互作用 p = 0.013）。 ECM 模式对 BM 风险的影响仅限于 HR−/HER2− 患者（趋势 p < 0.001），以骨转移为参考，肺转移会增加 BM 风险（OR = 1.936，95% CI：1.300–2.882，p = 0.001）。 T分期和ECM模式与不同分子亚型的BM有不同的关联。 HR−/HER2− BC 在 BM 发育上具有明显的特征，表现为缺乏肿瘤大小效应，并与肺转移相关。应考虑对 HR−/HER2− BC 患者进行密切监测 BM。在SEER数据库中选取的527,525名乳腺癌患者中，我们发现HR−/HER2−乳腺癌在脑转移的发展上具有明显的特征，表现为缺乏肿瘤大小效应并与肺转移相关。因此，应考虑对 HR−/HER2− 乳腺癌患者进行脑转移的密切监测。
Early detection of brain metastasis (BM) is essential for prognostic improvement in breast cancer (BC) patients. The aim was to identify predictors of BCBM in different molecular subtypes on a population‐based level. The Surveillance, Epidemiology, and End Results database was used to select BC patients diagnosed from 2010 to 2018. We evaluated the incidence and risk factors of BCBM and tested the interaction effects between molecular subtypes and other risk factors. Among the 527,525 selected patients, molecular subtypes significantly interacted with T stage and extracranial metastasis (ECM) patterns on the risk of BM in the whole BC population (interaction p = 0.002, <0.001, respectively) and after excluding patients with unknown states of key factors. BM development was independent of the T stage only in HR−/HER2− patients (trend p = 0.126). We selected BC patients with single‐organ ECM and found a significant interaction between molecular subtypes and ECM patterns (interaction p = 0.013). The impact of ECM patterns on the risk of BM was limited to HR−/HER2− patients (trend p < 0.001), for whom using bone metastasis as a reference, lung metastasis increased the risk of BM (OR = 1.936, 95% CI: 1.300–2.882, p = 0.001). T stage and ECM patterns had different associations with BM in different molecular subtypes. HR−/HER2− BC had distinct features on BM development, manifested as a lack of tumor size effect and is associated with lung metastasis. Close surveillance for BM should be considered for HR−/HER2− BC patients. Among the 527,525 selected breast cancer patients from SEER database, we found HR−/HER2− breast cancer had distinct features on the development of brain metastasis, manifested as a lack of tumor size effect and is associated with lung metastasis. Therefore, close surveillance for brain metastasis should be considered for HR−/HER2− breast cancer patients.
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影响因子：
4
作者：
Lin M;Jin Y;Jin J;Wang B;Hu X;Zhang J
通讯作者：
Zhang J
影响因子：
2.4
作者：
Min SK;Lee SK;Woo J;Jung SM;Ryu JM;Yu J;Lee JE;Kim SW;Chae BJ;Nam SJ
通讯作者：
Nam SJ
影响因子：
78.5
作者：
Klein, Christoph A.
通讯作者：
Klein, Christoph A.
DOI：
10.1007/s00432-018-2697-2
发表时间：
2018-09-01
影响因子：
3.6
作者：
Kim, Yi-Jun;Kim, Jae-Sung;Kim, In Ah
通讯作者：
Kim, In Ah
影响因子：
45.3
作者：
Gabos, Zsolt;Sinha, Richie;Abdulkarim, Bassam
通讯作者：
Abdulkarim, Bassam