Value encoding in the globus pallidus: fMRI reveals an interaction effect between reward and dopamine drive.
Value encoding in the globus pallidus: fMRI reveals an interaction effect between reward and dopamine drive.
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DOI：
10.1016/j.neuroimage.2018.02.048
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发表时间：
2018-06
期刊：
影响因子：
5.7
通讯作者：
Dolan RJ
中科院分区：
文献类型：
--
作者：
Fiore VG;Nolte T;Rigoli F;Smittenaar P;Gu X;Dolan RJ
苍白球 (GPe) 的外部是基底神经节 (BG) 的核心核，其活动在多巴胺释放量低的情况下会受到干扰，如帕金森病。目前的模型假设背侧纹状体中多巴胺释放的减少导致背侧 GPe 失活，这反过来又通过对 BG 其他核的调节作用影响运动表达。然而，最近对健康和病理动物模型的研究报告的神经动力学与 GPe 作为 BG 回路中的中继的观点并不相符。因此，GPe 在 BG 中的计算作用仍有待确定。我们之前提出了一个重新审视 BG 核功能的神经模型，该模型预测 GPe 编码的值在低纹状体多巴胺能驱动的条件下会被放大。为了测试这一预测，我们使用了功能磁共振成像范例，涉及受试者内安慰剂对照设计，使用多巴胺拮抗剂利培酮，其中健康志愿者在低和高奖励条件下执行运动选择和维持任务。基于 ROI 的 fMRI 分析揭示了奖励和多巴胺驱动操作之间的相互作用，与低奖励条件相比，在高奖励条件下，以及与安慰剂相比，在利培酮条件下 GPe 的 BOLD 活性增加。这些结果证实了我们计算模型的核心预测，并为 BG 中的神经动力学及其对运动选择和认知障碍的影响提供了新的视角。我们研究了基底神经节中动作状态值的表示。在多巴胺能驱动力减弱的情况下，GPe 的价值表达得到增强。在基础多巴胺能驱动下，SNr 的值表征得到增强。结果验证了提出的基底神经节神经模型。
The external part of the globus pallidus (GPe) is a core nucleus of the basal ganglia (BG) whose activity is disrupted under conditions of low dopamine release, as in Parkinson's disease. Current models assume decreased dopamine release in the dorsal striatum results in deactivation of dorsal GPe, which in turn affects motor expression via a regulatory effect on other nuclei of the BG. However, recent studies in healthy and pathological animal models have reported neural dynamics that do not match with this view of the GPe as a relay in the BG circuit. Thus, the computational role of the GPe in the BG is still to be determined. We previously proposed a neural model that revisits the functions of the nuclei of the BG, and this model predicts that GPe encodes values which are amplified under a condition of low striatal dopaminergic drive. To test this prediction, we used an fMRI paradigm involving a within-subject placebo-controlled design, using the dopamine antagonist risperidone, wherein healthy volunteers performed a motor selection and maintenance task under low and high reward conditions. ROI-based fMRI analysis revealed an interaction between reward and dopamine drive manipulations, with increased BOLD activity in GPe in a high compared to low reward condition, and under risperidone compared to placebo. These results confirm the core prediction of our computational model, and provide a new perspective on neural dynamics in the BG and their effects on motor selection and cognitive disorders. We investigate the representation of action-state values in the basal ganglia. Value representation is enhanced in the GPe under reduced dopaminergic drive. Value representation is enhanced in the SNr under basal dopaminergic drive. The results validate a proposed neural model of the basal ganglia.
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影响因子：
4.6
作者：
Fiore VG;Rigoli F;Stenner MP;Zaehle T;Hirth F;Heinze HJ;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
25
作者：
Doll, Bradley B.;Duncan, Katherine D.;Daw, Nathaniel D.
通讯作者：
Daw, Nathaniel D.
DOI：
10.1098/rstb.2015.0053
发表时间：
2015-12-19
影响因子：
6.3
作者：
Fiore, Vincenzo G.;Dolan, Raymond J.;Hirth, Frank
通讯作者：
Hirth, Frank
影响因子：
1.9
作者：
Gurney, K;Prescott, TJ;Redgrave, P
通讯作者：
Redgrave, P
DOI：
10.1073/pnas.1111715109
发表时间：
2012-02-07
影响因子：
11.1
作者：
Azzi, Joao C. B.;Sirigu, Angela;Duhamel, Jean-Rene
通讯作者：
Duhamel, Jean-Rene