A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis.
A novel vaccine targeting Fusobacterium nucleatum against abscesses and halitosis.
复制标题
一种针对脓肿和晕骨的新型疫苗，靶向核细菌。
DOI：
10.1016/j.vaccine.2008.12.058
复制
发表时间：
2009-03-04
期刊：
影响因子：
5.5
通讯作者：
Huang CM
中科院分区：
文献类型：
--
作者：
Liu PF;Haake SK;Gallo RL;Huang CM
由细菌感染引起的牙龈脓肿是慢性口臭的常见来源。虽然抗生素通常用于治疗脓肿，但需要多次治疗，并有产生耐药菌株的风险。在这里，我们使用紫外线灭活的具核梭杆菌（F. nucleatum）（一种口臭的代表性口腔细菌）开发了一种新型疫苗。采用通过连续接种具核梭杆菌建立的胶袋模型来验证疫苗效力。通过牙龈袋肿胀组织测量，用灭活具核梭杆菌免疫的小鼠有效地最大程度地减少了脓肿的进展。最值得注意的是，免疫小鼠能够引发针对具核梭菌挥发性硫化合物产生的中和抗体。这种诱导保护性免疫的新型疫苗为治疗与脓肿相关的慢性口臭提供了传统抗生素治疗的替代选择。
An abscess in a gum pocket, resulting from bacterial infection, is a common source of chronic halitosis. Although antibiotics are generally prescribed for abscesses, they require multiple treatments with risks of creating resistant bacterial strains. Here we develop a novel vaccine using ultraviolet-inactivated Fusobacterium nucleatum (F. nucleatum), a representative oral bacterium for halitosis. A gum pocket model, established by continuous inoculation of F. nucleatum, was employed to validate the vaccine potency. Mice immunized with inactivated F. nucleatum effectively minimized the progression of abscesses, measured by swollen tissues of gum pockets. Most notably, the immunized mice were capable of eliciting neutralizing antibodies against the production of volatile sulfur compounds of F. nucleatum. The novel vaccine inducing protective immunity provides an alternative option to conventional antibiotic treatments for chronic halitosis associated with abscesses.
登录
查看更多内容
影响因子：
3.1
作者：
MALLISON, SM;SMITH, JP;TEW, JG
通讯作者：
TEW, JG
影响因子：
82.9
作者：
Brockstedt, DG;Bahjat, KS;Dubensky, TW
通讯作者：
Dubensky, TW
影响因子：
4.6
作者：
Gemmell, E;Bird, PS;Seymour, GJ
通讯作者：
Seymour, GJ
影响因子：
3.1
作者：
NAITO, Y;OKUDA, K;TAKAZOE, I
通讯作者：
TAKAZOE, I
影响因子：
--
作者：
Saito, Y.;Fujii, R.;Ishihara, K.
通讯作者：
Ishihara, K.