Organoids of the Female Reproductive Tract: Innovative Tools to Study Desired to Unwelcome Processes.
Organoids of the Female Reproductive Tract: Innovative Tools to Study Desired to Unwelcome Processes.
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DOI：
10.3389/fcell.2021.661472
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发表时间：
2021
影响因子：
5.5
通讯作者：
Vankelecom H
中科院分区：
文献类型：
--
作者：
Heremans R;Jan Z;Timmerman D;Vankelecom H
女性生殖道的盆腔会阴器官是人类生殖的重要基石。该系统包括外胚层外生殖器、苗勒氏上阴道、宫颈、子宫内膜和输卵管衍生物以及内胚层卵巢。这些器官中的每一个都呈现出独特的生物发育过程以及恶性变性过程。几十年来，各种临床前体外模型已被用于研究女性生殖器官（病理）生物学，然而，面临着重要的缺点，有限的可扩展性，代表性的损失和临床翻译性不足。最近出现的3D类器官模型通过产生强大的研究工具推动了该领域的发展，这些研究工具可以在体外复制健康和患病的人体组织，并且可以进行最先进的实验干预。在这里，我们详细回顾了健康和致瘤背景下不同女性生殖器官的类器官建模，以及科学家和临床医生的项目前景。
The pelviperineal organs of the female reproductive tract form an essential cornerstone of human procreation. The system comprises the ectodermal external genitalia, the Müllerian upper-vaginal, cervical, endometrial and oviductal derivatives, and the endodermal ovaries. Each of these organs presents with a unique course of biological development as well as of malignant degeneration. For many decades, various preclinical in vitro models have been employed to study female reproductive organ (patho-)biology, however, facing important shortcomings of limited expandability, loss of representativeness and inadequate translatability to the clinic. The recent emergence of 3D organoid models has propelled the field forward by generating powerful research tools that in vitro replicate healthy as well as diseased human tissues and are amenable to state-of-the-art experimental interventions. Here, we in detail review organoid modeling of the different female reproductive organs from healthy and tumorigenic backgrounds, and project perspectives for both scientists and clinicians.
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影响因子：
4.7
作者：
Chen H;Gotimer K;De Souza C;Tepper CG;Karnezis AN;Leiserowitz GS;Chien J;Smith LH
通讯作者：
Smith LH
影响因子：
6.1
作者：
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Mizutani, S
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Boretto, Matteo;Cox, Benoit;Vankelecom, Hugo
通讯作者：
Vankelecom, Hugo
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通讯作者：
Fazeli, A.
影响因子：
6.1
作者：
Bläuer, M;Heinonen, PK;Ylikomi, T
通讯作者：
Ylikomi, T