Cannabis cue-elicited craving and the reward neurocircuitry.

Cannabis cue-elicited craving and the reward neurocircuitry.
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DOI:
10.1016/j.pnpbp.2011.11.001
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发表时间:
2012-07-02
影响因子:
5.6
通讯作者:
DeWitt, Samuel J.
DeWitt, Samuel J.
中科院分区:
医学2区
文献类型:
--
作者:
Filbey, Francesca M.;DeWitt, Samuel J.

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线索引发的渴望或在接触条件药物线索后对某种物质的强烈欲望是物质使用障碍(SODS)的主要行为症状之一。虽然暗示引发的渴望的概念在酒精和其他滥用物质中有很好的特征,但直到最近才在大麻中描述。对现有文献的回顾表明,线索引发的渴望是一种强大的增强剂,有助于寻找大麻的药物。此外,紧急研究已经开始确定与这种行为相关的神经生物学系统和神经机制。研究表明,尽管关于THC对多巴胺能奖赏系统的影响的理论仍存在分歧,但大麻线索可以诱导大脑奖赏网络中的神经激活。
Cue-elicited craving or the intense desire to consume a substance following exposure to a conditioned drug cue is one of the primary behavioral symptoms of substance use disorders (SUDs). While the concept of cue-elicited craving is well characterized in alcohol and other substances of abuse, only recently has it been described in cannabis. A review of the extant literature has established that cue-elicited craving is a powerful reinforcer that contributes to drug-seeking for cannabis. Further, emergent research has begun to identify the neurobiological systems and neural mechanisms associated with this behavior. What research shows is that while theories of THC’s effects on the dopaminergic-reward system remain divergent, cannabis cues elicit neural activation in the brain’s reward network.
DOI: 10.1038/npp.2009.200
发表时间: 2010-03
期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
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