The Extrinsic Coagulation Pathway: a Biomarker for Suicidal Behavior in Major Depressive Disorder.
The Extrinsic Coagulation Pathway: a Biomarker for Suicidal Behavior in Major Depressive Disorder.
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外在凝血途径：重度抑郁症自杀行为的生物标志物。
DOI：
10.1038/srep32882
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发表时间：
2016-09-08
影响因子：
4.6
通讯作者：
Xie P
中科院分区：
文献类型：
--
作者：
Yang Y;Chen J;Liu C;Fang L;Liu Z;Guo J;Cheng K;Zhou C;Zhan Y;Melgiri ND;Zhang L;Zhong J;Chen J;Rao C;Xie P
虽然重度抑郁症（MDD）和自杀之间存在关联，但大多数抑郁症患者从未尝试自杀。对导致MDD自杀风险的因素的进一步了解可以为自杀预测因子的开发提供方向。在MDD自杀未遂者（MDD-SA）、MDD非自杀未遂者（MDD-NA）和健康对照者（HC）（每组n = 12）中，互补血浆蛋白质组学鉴定了45种定位于凝血和炎症的差异蛋白，其中25种进行了Western印迹。在另一个包括抗抑郁药治疗患者的队列（每组n = 49）中，选择了7种额外的外源性途径蛋白进行ELISA。两个炎性蛋白和八个凝血蛋白表现出改变MDD-SA相对于MDD-NA和HC。应用相对质量作用比，MDD-SA受试者显示出比MDD-NA受试者更高的相对凝血酶原酶活性，而健康对照组显示出比MDD-SA和MDD-NA受试者更高的相对凝血酶原酶活性。与我们的人类研究结果一致，我们发现肝素治疗显著增加了啮齿动物的强迫游泳试验（FST）不动时间。MDD独立于自杀倾向，与促炎状态伴血栓形成状态相关。MDD中的自杀行为与更明显的促炎和促血栓形成表型相关，伴有外源性途径激活，揭示了可用于预测和监测自杀风险的外源性途径生物标志物。
Although an association between major depressive disorder (MDD) and suicide exists, most depressed patients never attempt suicide. An improved understanding of the factors contributing to suicidal risk in MDD can provide direction for suicide predictor development. In MDD suicide attempters (MDD-SA), MDD non-attempters (MDD-NA), and healthy controls (HC) (n = 12 each group), complementary plasma proteomics identified 45 differential proteins mapped to coagulation and inflammation, 25 of which underwent Western blotting. In another cohort including antidepressant-treated patients (n = 49 each group), seven additional extrinsic pathway proteins were selected for ELISA. Two inflammatory proteins and eight coagulatory proteins demonstrated alterations in MDD-SA relative to MDD-NA and HC. Applying a relative mass-action ratio, MDD-SA subjects displayed a higher relative prothrombinase activity than MDD-NA subjects, while healthy controls displayed higher relative prothrombinase activity than both MDD-SA and MDD-NA subjects. Consistent with our human findings, we found that heparin treatment significantly increased forced swimming test (FST) immobility time in rodents. MDD, independent of suicidality, is associated with a proinflammatory state accompanied by a hypothrombotic state. Suicidal behavior in MDD is associated with a more pronounced proinflammatory and prothrombotic phenotype accompanied by extrinsic pathway activation, revealing an extrinsic pathway biomarker that can be applied in predicting and monitoring suicidal risk.
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影响因子：
6.6
作者：
Blair-West, GW;Cantor, CH;Eyeson-Annan, ML
通讯作者：
Eyeson-Annan, ML
影响因子：
7.5
作者：
Fischer, F;Appert-Flory, A;Toulon, P
通讯作者：
Toulon, P
影响因子：
11.3
作者：
Jokinen, Jussi;Carlborg, Andreas;Nordstrom, Peter
通讯作者：
Nordstrom, Peter
DOI：
10.1111/j.1749-6632.1986.tb27883.x
发表时间：
1986-01-01
影响因子：
5.2
作者：
Cohen, J
通讯作者：
Cohen, J
影响因子：
1.9
作者：
Geiser, Franziska;Gessler, Katharina;Harbrecht, Ursula
通讯作者：
Harbrecht, Ursula