Oral Tissue Responses to Travel in Space

Oral Tissue Responses to Travel in Space
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口腔组织对太空旅行的反应

DOI:
10.5772/intechopen.86728
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发表时间:
2019
期刊:
Space Medicine [Working Title]
影响因子:
--
通讯作者:
A. Hand
A. Hand
中科院分区:
--
文献类型:
--
作者:
M. Mednieks;A. Hand

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口腔具有味觉、咀嚼、营养物质的溶解和消化功能,以及呼吸和言语功能,并参与先天性和适应性免疫。唾液创造并调节口腔环境,其成分和分泌速率的变化对口腔组织以及全身健康具有重大影响。研究人员在美国航天飞机 STS-131 和 STS-135 任务以及俄罗斯 Bion-M1 生物卫星上飞行的小鼠身上研究了微重力对唾液腺、下颌骨和牙齿的影响。腮腺形态和分泌蛋白表达发生显着变化;下颌下腺仅在为期 30 天的 Bion-M1 任务中受到影响,这表明由于重力变化而产生的影响的组织特异性,这可能与人类中发生的情况类似。下颌骨和门牙也发生了变化。唾液收集是一种非侵入性程序,用于评估生理状态和诊断多种疾病,并为监测宇航员在长时间太空飞行期间的健康状况提供了一种简单的方法。 μ m) 来自每个下颌。在我们的研究中,对每个下颌骨 10 个连续切片(120 μm 跨度)的结果进行了平均,提供了更具代表性的测量结果。
The oral cavity functions in taste, mastication, solubilization and digestion of nutrients, as well as in respiration and speech, and participates in innate and adaptive immunity. Saliva creates and regulates the environment of the oral cavity, and changes in its composition and rate of secretion have significant effects on oral tissues as well as on systemic health. The effects of microgravity on the salivary glands, mandible and teeth were studied in mice flown on US space shuttle STS-131 and STS-135 missions, and the Russian Bion-M1 biosatellite. Significant changes in morphology and secretory protein expression occurred in parotid glands; submandibular glands were affected only on the 30-day Bion-M1 mission, indicating tissue specificity of the effects due to changes in gravity which may be similar to those taking place in humans. Changes also occurred in mandibular bone and incisor teeth. Collection of saliva is a non-invasive procedure for assessing physiological status and diagnosis of several disorders and provides a simple method for monitoring astronaut health during extended spaceflight. μ m) from each mandible. In our study the results from 10 serial sections (120 μ m span) per mandible were averaged, providing a more representa-tive measurement.
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