Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan.
Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan.
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DOI：
10.1016/j.arr.2011.12.006
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发表时间：
2012-04
影响因子：
13.1
通讯作者：
Swindell, William R.
中科院分区：
文献类型：
--
作者：
Swindell, William R.
关键词：
实验室生存实验表明，饮食限制（DR）可以增加中位寿命和最长寿命。本文提供了一个荟萃分析的实验室实验，评估了DR对大鼠和小鼠寿命的影响（1934年至今）。在一半的实验中，DR使大鼠的中位寿命延长了14 - 45%，但在小鼠中，DR的影响要弱得多（4 - 27%）。在近交系而非非近交系小鼠品系中观察到DR对寿命的最不利影响。事实上，一些近交系小鼠品系不一定与DR一起活得更长，包括DBA/2雄性小鼠和来自ILSXISS重组近交系组的几个品系。在ILSXISS菌株114中也观察到并证实了DR的寿命缩短。重要的是，所有啮齿类动物研究可能会受到实验室育种影响的影响，因为一项研究表明，野生小鼠的中位寿命不会因DR而改善。这些发现表明，在啮齿动物DR实验中研究的遗传背景集应该是多样化的。这将拓宽衰老研究中基因型研究的范围，但也可能是关键的研究结果从啮齿动物的历史远交和遗传异质性灵长类物种的翻译。
Laboratory survival experiments have shown that dietary restriction (DR) can increase median and maximum lifespan. This paper provides a meta-analysis of laboratory experiments that have evaluated the effects of DR on lifespan in rats and mice (1934 – present). In rats, DR increased median lifespan by 14 – 45% in half of all experiments, but in mice the effects of DR have been much weaker (4 – 27%). The least favorable effects of DR on lifespan have been observed among inbred rather than non-inbred mouse strains. In fact, some inbred mouse strains do not necessarily live longer with DR, including DBA/2 male mice and several strains from the ILSXISS recombinant inbred panel. Shortening of lifespan with DR has also been observed and confirmed for ILSXISS strain 114. Importantly, all rodent studies may be biased by the effects of laboratory breeding, since one study has shown that median lifespan is not improved by DR in wild-derived mice. These findings suggest that the set of genetic backgrounds studied in rodent DR experiments should be diversified. This will broaden the scope of genotypes studied in aging research, but may also be critical for translation of findings from rodents to historically outbred and genetically heterogeneous primate species.
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影响因子：
7.8
作者：
Fontana L;Weiss EP;Villareal DT;Klein S;Holloszy JO
通讯作者：
Holloszy JO
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
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影响因子：
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作者：
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通讯作者：
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