Increased self-reported impulsivity in methamphetamine users maintaining drug abstinence.
Increased self-reported impulsivity in methamphetamine users maintaining drug abstinence.
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DOI：
10.1080/00952990.2016.1192639
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
London ED
中科院分区：
文献类型：
--
作者：
Jones HW;Dean AC;Price KA;London ED
冲动性被认为是成瘾的开始和维持的一个重要因素。间接证据表明，一些甲基苯丙胺使用者报告说，与戒断时相比，他们使用甲基苯丙胺时的冲动性较低，但这一假设尚未得到直接检验。在这项研究中，自我报告的冲动获得了32甲基苯丙胺依赖（DSM-IV）的研究参与者和41名健康对照组，使用Barratt冲动量表-11。在甲基苯丙胺使用活跃期（通过尿液分析确定）和确认戒断约一周后再次对甲基苯丙胺使用者进行评估。对照组受试者同样完成了两项评估。一部分参与者还完成了贝克抑郁量表（甲基苯丙胺组，N = 17，对照组，N = 38）和甲基苯丙胺戒断问卷（甲基苯丙胺组，N = 12）的系列评估。有一个显着的相互作用组与时间的冲动（p = 0.044），反映了显着增加，从第一次到第二次评估的甲基苯丙胺用户（p=0.013），但没有变化的健康对照组。相比之下，甲基苯丙胺使用者的抑郁和戒断症状在第一次和第二次评估之间显著减少（p ≤ 0.01）。甲基苯丙胺使用者冲动性的变化与戒断或抑郁的变化没有显着相关性（p> 0.05）。这些研究结果表明，甲基苯丙胺使用者报告更多的冲动时，从药物使用，效果是没有显着相关的甲基苯丙胺戒断。冲动的减弱可能会加强这些人继续使用甲基苯丙胺。
Impulsivity has been proposed as an important factor in the initiation and maintenance of addiction. Indirect evidence suggests that some methamphetamine users report less impulsivity when they are using methamphetamine compared to when abstinent, but this hypothesis has not been directly tested. In this study, self-reports of impulsivity were obtained from 32 methamphetamine-dependent (DSM-IV) research participants and 41 healthy control subjects, using the Barratt Impulsiveness Scale-11. The methamphetamine users were assessed during an active period of methamphetamine use, as determined through urinalysis, and again after approximately one week of confirmed abstinence. Control subjects likewise completed two assessments. A subset of participants also completed serial assessments of the Beck Depression Inventory (Methamphetamine Group, N = 17, Control Group, N = 38) and the Methamphetamine Withdrawal Questionnaire (Methamphetamine Group, N = 12). There was a significant interaction of group with time on impulsivity (p = 0.044), reflecting a significant increase from the first to the second assessment in the methamphetamine users (p=0.013), but no change among healthy control subjects. In contrast, depressive and withdrawal symptoms significantly decreased between the first and second assessment in the methamphetamine users (p’s ≤ 0.01). Change in impulsivity in methamphetamine users was not significantly correlated with change in withdrawal or depression (p’s > 0.05). These findings suggest that methamphetamine users report more impulsivity when abstaining from drug use, an effect that is not significantly related to methamphetamine withdrawal. Attenuation of impulsivity may reinforce continued methamphetamine use in these individuals.
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影响因子：
4.2
作者：
Dean, Andy C.;Kohno, Milky;Morales, Angelica M.;Ghahremani, Dara G.;London, Edythe D.
通讯作者：
London, Edythe D.
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF
影响因子：
7.6
作者：
Moeller, FG;Hasan, KM;Narayana, PA
通讯作者：
Narayana, PA
影响因子：
3
作者：
Mitchell, John T.;McIntyre, Elizabeth M.;Kollins, Scott H.
通讯作者：
Kollins, Scott H.
影响因子：
7
作者：
Morris, SB;DeShon, RP
通讯作者：
DeShon, RP