Similarities and Differences in Associations Between Duration of Untreated Psychosis (DUP) and Demographic, Premorbid, and Symptom Severity Measures in Two Samples of First-Episode Psychosis Patients from Mexico and the United States.
Similarities and Differences in Associations Between Duration of Untreated Psychosis (DUP) and Demographic, Premorbid, and Symptom Severity Measures in Two Samples of First-Episode Psychosis Patients from Mexico and the United States.
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DOI：
10.1007/s11126-020-09736-3
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Compton MT
中科院分区：
文献类型：
--
作者：
Fresan A;Apiquian R;Robles-García R;Zarate CT;Balducci PM;Broussard B;Wan CR;Compton MT
早期精神病研究人员已经证明，未经治疗的精神病持续时间（DUP）是首次发作精神病结果的重要预测因素。很少有跨国研究已经进行，并没有进行涉及来自墨西哥和美国的患者，我们合作回答三个问题：（1）DUP估计在两个非常不同的设置和样本相似？（2）人口统计学变量、病前调整和症状严重程度是否在两种不同的环境中与DUP相似？（3）同一组变量在两种情况下是否占DUP方差的相似比例？145名墨西哥和247名美国首发精神病患者的社会人口学特征、病前调整、症状严重程度和DUP数据可用。比较DUP，并对每个样本进行双变量分析和多元线性回归。DUP估计值相似（墨西哥的中位数为35周，美国为38周）。在墨西哥样本中，DUP与性别、就业状况、病前社会适应和阳性症状严重程度相关（解释18%的方差）。在美国样本中，DUP与年龄、就业状况、病前社会适应和阳性症状严重程度相关（但与墨西哥样本中观察到的方向相反），占方差的25%。更多的跨国合作研究早期精神障碍的关键方面，包括DUP，将澄清结果的普遍性程度，加强更多国际相关研究的伙伴关系，并支持全球运动，以帮助与首发精神病及其家庭作斗争的年轻人。
Early-psychosis researchers have documented that duration of untreated psychosis (DUP) is an important predictor of outcomes in first-episode psychosis. Very few cross-national studies have been conducted, and none have been carried out involving patients from both Mexico and the U.S. We collaborated to answer three questions: (1)Are DUP estimates similar in two very different settings and samples? (2)Are demographic variables, premorbid adjustment, and symptom severity similarly related to DUP in the two different settings? (3)Does the same set of variables account for a similar proportion of variance in DUP in the two settings? Data on sociodemographic characteristics, premorbid adjustment, symptom severity, and DUP were available for 145 Mexican and 247 U.S. first-episode psychosis patients. DUP was compared, and bivariate analyses and multiple linear regressions were carried out in each sample. DUP estimates were similar (medians of 35 weeks in Mexico and 38 weeks in the U.S.). In the Mexican sample, DUP was associated with gender, employment status, premorbid social adjustment, and positive symptom severity (explaining 18% of variance). In the U.S. sample, DUP was associated with age, employment status, premorbid social adjustment, and positive symptom severity (but in the opposite direction of that observed in the Mexican sample), accounting for 25% of variance. Additional cross-national collaborations examining key facets of early-course psychotic disorders, including DUP, will clarify the extent of generalizability of findings, strengthen partnerships for more internationally relevant studies, and support the global movement to help young people struggling with first-episode psychosis and their families.
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影响因子：
3.1
作者：
Cechnicki, Andrzej;Hanuszkiewicz, Igor;Bielanska, Anna
通讯作者：
Bielanska, Anna
影响因子：
5.3
作者：
Compton, Michael T.;Gordon, Tynessa L.;Kaslow, Nadine J.
通讯作者：
Kaslow, Nadine J.
影响因子：
2
作者：
Hui, Christy Lai-Ming;Lau, Winnie Wing-Yin;Chen, Eric Yu-Hai
通讯作者：
Chen, Eric Yu-Hai
影响因子：
5.3
作者：
Compton, Michael T.;Gordon, Tynessa L.;Walker, Elaine F.
通讯作者：
Walker, Elaine F.
影响因子：
6.4
作者：
Del Rey-Mejias, Angel;Fraguas, David;Parellada, Mara
通讯作者：
Parellada, Mara