All Roads Lead to Susceptibility: The Many Modes of Action of Fungal and Oomycete Intracellular Effectors.
All Roads Lead to Susceptibility: The Many Modes of Action of Fungal and Oomycete Intracellular Effectors.
复制标题
所有道路都会引起敏感性：真菌和卵菌的细胞内效应子的许多作用方式。
DOI：
10.1016/j.xplc.2020.100050
复制
发表时间：
2020-07-13
影响因子：
10.5
通讯作者：
Birch PRJ
中科院分区：
文献类型：
--
作者：
He Q;McLellan H;Boevink PC;Birch PRJ
分泌能够进入植物细胞并操纵寄主过程的效应蛋白的能力是决定植物病原菌成功与否的关键因素。在这里，我们回顾了丝状(真菌和卵菌)植物病原体的细胞内效应因子以及促进疾病的宿主蛋白和过程。我们涵盖了不同的毒性策略和效应者的行动模式。丝状病原体效应器改变它们所针对的宿主蛋白的命运，改变它们的稳定性、它们的活性、它们的位置以及它们相互作用的蛋白质伙伴。一些效应器抑制靶标活性，而另一些则增强或利用它，还有一些靶标是多宿主蛋白。我们讨论了以免疫负调节因子或其他具有支持敏感性的活性的植物蛋白为靶标的效应器这一新兴话题。我们还强调了常见的靶向宿主蛋白，这些蛋白被来自多个病原体的效应器操纵，包括代表不同生命王国的那些。近年来，人们越来越努力地识别真菌和卵菌产生的细胞内效应物的靶标。本文综述了效应器靶标在植物免疫调控中的作用，以及真菌和卵菌效应器在宿主中操纵这些调控过程的相关作用模式。
The ability to secrete effector proteins that can enter plant cells and manipulate host processes is a key determinant of what makes a successful plant pathogen. Here, we review intracellular effectors from filamentous (fungal and oomycete) phytopathogens and the host proteins and processes that are targeted to promote disease. We cover contrasting virulence strategies and effector modes of action. Filamentous pathogen effectors alter the fates of host proteins that they target, changing their stability, their activity, their location, and the protein partners with which they interact. Some effectors inhibit target activity, whereas others enhance or utilize it, and some target multiple host proteins. We discuss the emerging topic of effectors that target negative regulators of immunity or other plant proteins with activities that support susceptibility. We also highlight the commonly targeted host proteins that are manipulated by effectors from multiple pathogens, including those representing different kingdoms of life. Recent years have seen increased efforts to identify the targets of intracellular effectors produced by fungi and oomycetes. This review describes the roles played by effector targets in the control of plant immunity and the associated modes of action by which fungal and oomycete effectors manipulate these regulatory processes in the host.
登录
查看更多内容
DOI：
10.1073/pnas.1808585115
发表时间：
2018-08-14
影响因子：
11.1
作者：
He Q;Naqvi S;McLellan H;Boevink PC;Champouret N;Hein I;Birch PRJ
通讯作者：
Birch PRJ
影响因子：
7.7
作者：
Dagdas YF;Pandey P;Tumtas Y;Sanguankiattichai N;Belhaj K;Duggan C;Leary AY;Segretin ME;Contreras MP;Savage Z;Khandare VS;Kamoun S;Bozkurt TO
通讯作者：
Bozkurt TO
影响因子：
16.6
作者：
Boevink PC;Wang X;McLellan H;He Q;Naqvi S;Armstrong MR;Zhang W;Hein I;Gilroy EM;Tian Z;Birch PRJ
通讯作者：
Birch PRJ
细菌效应器设计和功能的常见主题。
影响因子：
30.3
作者：
Galan, Jorge E.
通讯作者：
Galan, Jorge E.
影响因子：
9.8
作者：
Gimenez-Ibanez S;Boter M;Fernández-Barbero G;Chini A;Rathjen JP;Solano R
通讯作者：
Solano R