Short Report: Early genomic detection of SARS-CoV-2 P.1 variant in Northeast Brazil.
Short Report: Early genomic detection of SARS-CoV-2 P.1 variant in Northeast Brazil.
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DOI：
10.1371/journal.pntd.0009591
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发表时间：
2021-07
影响因子：
3.8
通讯作者：
Leal A
中科院分区：
文献类型：
--
作者：
Tosta S;Giovanetti M;Brandão Nardy V;Reboredo de Oliveira da Silva L;Kelly Astete Gómez M;Gomes Lima J;Wanderley Cardoso C;Oliveira Silva T;São Pedro Leal de Souza M;Presta Dias PH;Fonseca V;de Oliveira T;Lourenço J;Carlos Junior Alcantara L;Pereira F;Leal A
追踪令人担忧的新冠病毒（SARS-CoV - 2）变异株的传播对于为公共卫生工作提供信息以及控制正在发生的大流行至关重要。在此，我们报告了巴西东北部存在P.1变异株传播的基因证据。我们主张加强主动监测，以确保在全国范围内对该变异株进行充分控制。
近几个月来，新冠病毒刺突蛋白上有更多突变的变异株引起了全世界的关注。这些变异株被称为“令人担忧的变异株”（VOC），因为据推测它们的基因组突变可能会影响传播、免疫控制和毒力。P.1变异株，也称为20J/501Y.V3，于2021年1月初在日本东京的机场例行筛查中，在来自巴西的旅客中首次被发现。这种令人担忧的变异株有17个氨基酸变化，其中10个在其刺突蛋白上，包括三个被特别关注的位点：N501Y、E484K和K417T。自首次被检测到以来，尽管它在全球持续传播，但关于它在巴西各地区的传播情况仍有很多未知之处。在此，通过巴伊亚州（巴西东北部）公共卫生当局进行的主动监测，我们报告了P.1变异株在该州传播的基因证据。我们的研究结果强调，需要持续的基因组监测策略来协助监测和了解正在传播以及共同传播的新冠病毒变异株，这可能有助于减轻它们在全球范围内对公共卫生的影响。
Tracking the spread of SARS-CoV-2 variants of concern is crucial to inform public health efforts and control the ongoing pandemic. Here, we report genetic evidence for circulation of the P.1 variant in Northeast Brazil. We advocate for increased active surveillance to ensure adequate control of this variant throughout the country. In recent months’ variants of SARS-CoV-2 that have more mutations on the Spike protein has brought concern all over the world. These have been called ‘variants of concern’ (VOC) as it has been suggested that their genome mutations might impact transmission, immune control, and virulence. The P.1 variant, also known as 20J/501Y.V3, was first identified in travelers from Brazil during routine airport screening in Tokyo, Japan, in early January 2021. This VOC has 17 amino acid changes, ten of which are in its spike protein, including three designated to be of particular concern: N501Y, E484K and K417T. Since its first detection, despite it has presented sustained transmission worldwide, much is still unknown about its circulation into Brazilian regions. Here, through an active monitoring conducted by public health authorities of the Bahia state (Northeast Brazil), we report genetic evidence for circulation of the P.1 variant into the state. Our findings reinforce that continued genomic surveillance strategies are needed to assist in the monitoring and understanding of the circulating and co-circulating SARS-CoV-2 variants, which might help to attenuate their public health impact worldwide.
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影响因子：
7.7
作者：
Weisblum Y;Schmidt F;Zhang F;DaSilva J;Poston D;Lorenzi JC;Muecksch F;Rutkowska M;Hoffmann HH;Michailidis E;Gaebler C;Agudelo M;Cho A;Wang Z;Gazumyan A;Cipolla M;Luchsinger L;Hillyer CD;Caskey M;Robbiani DF;Rice CM;Nussenzweig MC;Hatziioannou T;Bieniasz PD
通讯作者：
Bieniasz PD
影响因子：
11.8
作者：
Nonaka CKV;Franco MM;Gräf T;de Lorenzo Barcia CA;de Ávila Mendonça RN;de Sousa KAF;Neiva LMC;Fosenca V;Mendes AVA;de Aguiar RS;Giovanetti M;de Freitas Souza BS
通讯作者：
de Freitas Souza BS
DOI：
10.1093/bioinformatics/bty695
发表时间：
2019-03-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Vilsker M;Moosa Y;Nooij S;Fonseca V;Ghysens Y;Dumon K;Pauwels R;Alcantara LC;Vanden Eynden E;Vandamme AM;Deforche K;de Oliveira T
通讯作者：
de Oliveira T
影响因子：
82.9
作者：
Naveca, Felipe Gomes;Nascimento, Valdinete;Bello, Gonzalo
通讯作者：
Bello, Gonzalo
DOI：
10.1126/science.abh2644
发表时间：
2021-05-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Faria NR;Mellan TA;Whittaker C;Claro IM;Candido DDS;Mishra S;Crispim MAE;Sales FCS;Hawryluk I;McCrone JT;Hulswit RJG;Franco LAM;Ramundo MS;de Jesus JG;Andrade PS;Coletti TM;Ferreira GM;Silva CAM;Manuli ER;Pereira RHM;Peixoto PS;Kraemer MUG;Gaburo N Jr;Camilo CDC;Hoeltgebaum H;Souza WM;Rocha EC;de Souza LM;de Pinho MC;Araujo LJT;Malta FSV;de Lima AB;Silva JDP;Zauli DAG;Ferreira ACS;Schnekenberg RP;Laydon DJ;Walker PGT;Schlüter HM;Dos Santos ALP;Vidal MS;Del Caro VS;Filho RMF;Dos Santos HM;Aguiar RS;Proença-Modena JL;Nelson B;Hay JA;Monod M;Miscouridou X;Coupland H;Sonabend R;Vollmer M;Gandy A;Prete CA Jr;Nascimento VH;Suchard MA;Bowden TA;Pond SLK;Wu CH;Ratmann O;Ferguson NM;Dye C;Loman NJ;Lemey P;Rambaut A;Fraiji NA;Carvalho MDPSS;Pybus OG;Flaxman S;Bhatt S;Sabino EC
通讯作者：
Sabino EC