A facile method for synthesizing polymeric nanofiber‐fragments

A facile method for synthesizing polymeric nanofiber‐fragments
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一种合成聚合物纳米纤维碎片的简便方法

DOI:
10.1002/nano.202100194
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发表时间:
2021
期刊:
Nano Select
影响因子:
--
通讯作者:
Nam, Jin
Nam, Jin
中科院分区:
--
文献类型:
--
作者:
Banerjee, Aihik;Jariwala, Tanvi;Kim, Sanggon;Tai, Youyi;Chiang, Sharon;Park, Honghyun;Myung, Nosang V.;Nam, Jin

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静电纺丝是一种从几乎所有聚合物合成纳米纤维结构的通用方法,为广泛应用的纳米材料的工业规模大规模生产提供了解决方案。然而,静电纺丝纤维固有的连续非织造结构限制了它们的应用,其中需要较小的长度尺度。在这里,我们提出了一种基于聚合物和牺牲二氧化硅纳米颗粒的胶体静电纺丝,然后用超声波进行机械破碎的新方法来合成聚合物纳米碎片。二氧化硅纳米颗粒的尺寸和疏水性被优化以改善其在聚合物基质中的整合,并且显示了二氧化硅纳米颗粒负载量对β-片段长度的可控性,对于平均纤维直径约为100 nm的聚(偏二氟乙烯-三氟乙烯)纳米纤维,其长度低至2 μm。所得到的β-碎片显示出保持其材料特性,包括压电系数,并且用动物模型证明了其用于药物递送应用的增强的可注射性。
Electrospinning is a versatile method for synthesizing nanofibrous structures from nearly all polymers, offering a solution for the industrial‐scale mass production of nanomaterials in a wide range of applications. However, the continuous non‐woven structure intrinsic to electrospun fibers limits their applications, where a smaller length scale is desired. Here, we present a novel method to synthesize polymeric nanofiber‐fragments based on colloid electrospinning of polymer and sacrificial silica nanoparticles, followed by mechanical fracturing with ultrasonication. The size and hydrophobicity of silica nanoparticles are optimized for their improved integration within the polymer matrix, and the controllability of nanofiber‐fragment length by the amount of silica nanoparticle loading, down to 2 µm in length for poly(vinylidene fluoride‐trifluoroethylene) nanofibers with an average fiber diameter of approximately 100 nm, is shown. The resultant nanofiber‐fragments are shown to maintain their material properties including piezoelectric coefficients and their enhanced injectability for drug delivery application is demonstrated with an animal model.
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影响因子: 14
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