Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease.
Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease.
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DOI：
10.1111/1753-0407.13303
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发表时间：
2022-09
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
表皮功能受许多外源性和内源性因素的调节，包括年龄、心理应激、某些皮肤疾病、紫外线照射和污染，并且表皮功能本身可以调节皮肤和皮外功能。角质层的生物物理性质反映了表皮功能和全身状况的状态。2型糖尿病在小鼠模型和人类中均显示表皮功能的改变，包括角质层水合水平降低和表皮渗透性增加以及渗透性屏障恢复延迟，这些都可以引起和加剧皮肤炎症。由于炎症在2型糖尿病中起致病作用，因此改善表皮功能的治疗可能是减轻2型糖尿病及其相关皮肤疾病的替代方法。2型糖尿病患者表现为表皮功能障碍。表皮功能障碍可引起皮肤和皮外炎症。由于炎症在2型糖尿病中的致病作用，表皮功能的改善可能有益于2型糖尿病。 亮点
Epidermal function is regulated by numerous exogenous and endogenous factors, including age, psychological stress, certain skin disorders, ultraviolet irradiation and pollution, and epidermal function itself can regulate cutaneous and extracutaneous functions. The biophysical properties of the stratum corneum reflect the status of both epidermal function and systemic conditions. Type 2 diabetes in both murine models and humans displays alterations in epidermal functions, including reduced levels of stratum corneum hydration and increased epidermal permeability as well as delayed permeability barrier recovery, which can all provoke and exacerbate cutaneous inflammation. Because inflammation plays a pathogenic role in type 2 diabetes, a therapy that improves epidermal functions could be an alternative approach to mitigating type 2 diabetes and its associated cutaneous disorders. Individuals with type 2 diabetes display epidermal dysfunction. Epidermal dysfunction can provoke cutaneous and extracutaneous inflammation. Because of the pathogenic role of inflammation in type 2 diabetes, improvements in epidermal functions could benefit type 2 diabetes. Highlights
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影响因子：
6.5
作者：
Fluhr, JW;Mao-Qiang, M;Elias, PM
通讯作者：
Elias, PM
影响因子：
6.5
作者：
Choi, EH;Brown, BE;Feingold, KR
通讯作者：
Feingold, KR
影响因子：
6.5
作者：
Aberg, Karin M.;Man, Mao-Qiang;Elias, Peter M.
通讯作者：
Elias, Peter M.
影响因子：
2.9
作者：
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通讯作者：
Cheing, Gladys L. Y.
影响因子：
6
作者：
Elias, Peter M.;Arbiser, Jack;Feingold, Kenneth R.
通讯作者：
Feingold, Kenneth R.