Chromatin in the nuclear landscape.
Chromatin in the nuclear landscape.
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DOI：
10.1101/sqb.2010.75.052
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Reinberg D
中科院分区：
文献类型：
--
作者：
Beck DB;Bonasio R;Kaneko S;Li G;Li G;Margueron R;Oda H;Sarma K;Sims RJ 3rd;Son J;Trojer P;Reinberg D
Chromatin affects many, if not all aspects, of nuclear organization and function. For this reason, we have focused our attention on elucidating some of the basic mechanisms regulating the formation and maintenance of chromatin, specifically concerning Polycomb repressive complex 2 (PRC2) and PR-Set7. PRC2 is responsible for catalyzing trimethylation of lysine 27 of histone H3 and thus has a critical role in the formation of facultative heterochromatin. PR-Set7 is responsible for catalyzing monomethylation of lysine 20 of histone H4 and is required for proper cell cycle progression and DNA damage response. We have also expanded our work to establish novel techniques and approaches to determine how chromatin is spatially regulated within the nuclear landscape.
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