Selection of the appropriate method for the assessment of insulin resistance.
Selection of the appropriate method for the assessment of insulin resistance.
复制标题
DOI：
10.1186/1471-2288-11-158
复制
发表时间：
2011-11-23
影响因子：
4
通讯作者：
Ferns G
中科院分区：
文献类型：
--
作者：
Borai A;Livingstone C;Kaddam I;Ferns G
胰岛素抵抗是代谢综合征的主要加重因素之一。有许多方法可用于估计胰岛素抵抗，从复杂的技术到简单的指数。对于所有评估胰岛素抵抗的方法，在将其用于调查之前，建立其有效性和可靠性是至关重要的。高胰岛素-正常血糖钳夹技术及其替代方法--频繁静脉葡萄糖耐量试验是评估胰岛素抵抗最可靠的方法。然而，许多可以从中得出指数的简单方法已经被评估和验证，例如稳态模型评估(HOMA)、定量胰岛素敏感性检查指数(QUICI)。由于IR的简单指数越来越多，临床医生和研究人员可能很难为他们的研究选择最合适的指数。因此，这项审查提供了在进行研究之前必须考虑的指导方针和建议。
Insulin resistance is one of the major aggravating factors for metabolic syndrome. There are many methods available for estimation of insulin resistance which range from complex techniques down to simple indices. For all methods of assessing insulin resistance it is essential that their validity and reliability is established before using them as investigations. The reference techniques of hyperinsulinaemic euglycaemic clamp and its alternative the frequently sampled intravenous glucose tolerance test are the most reliable methods available for estimating insulin resistance. However, many simple methods, from which indices can be derived, have been assessed and validated e.g. homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI). Given the increasing number of simple indices of IR it may be difficult for clinicians and researchers to select the most appropriate index for their studies. This review therefore provides guidelines and advices which must be considered before proceeding with a study.
登录
查看更多内容
影响因子：
7.2
作者：
Disse, E.;Bastard, J. P.;Laville, M.
通讯作者：
Laville, M.
影响因子：
8.2
作者：
Albareda, M;Rodríguez-Espinosa, J;Corcoy, R
通讯作者：
Corcoy, R
影响因子：
7.2
作者：
Choukem, S. -P.;Gautier, J. -F
通讯作者：
Gautier, J. -F
影响因子：
16.2
作者：
Bonora, E;Saggiani, F;Muggeo, M
通讯作者：
Muggeo, M
影响因子：
6.8
作者：
Balion, Cynthia M.;Raina, Parminder S.;Hunt, Dereck L.
通讯作者：
Hunt, Dereck L.