Validation of multiple equations for estimating low-density lipoprotein cholesterol levels in Korean adults.
Validation of multiple equations for estimating low-density lipoprotein cholesterol levels in Korean adults.
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DOI：
10.1186/s12944-021-01525-6
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发表时间：
2021-09-20
影响因子：
4.5
通讯作者：
Lee EH
中科院分区：
文献类型：
--
作者：
Choi R;Park MJ;Oh Y;Kim SH;Lee SG;Lee EH
可用于验证韩国成年人群低密度脂蛋白胆固醇（LDL）计算（LDLcal）的数据有限。本研究的目的是开发和验证一种新的LDLcal方程，并将其与韩国人群中以前的此类方程进行比较。开发了一个新的LDLcal方程（LDLChoi）。应用LDLChoi和其他11个先前发表的方程，并与开发队列（人群1）、同一实验室的独立验证队列（人群2）和韩国国家健康和营养检查调查2017队列（人群3）中直接测量的LDL浓度（LDLdirect）进行比较。在12个方程中，新开发的方程（LDLChoi =总胆固醇- 0.87 x高密度脂蛋白胆固醇- 0.13 x甘油三酯）在人群1和人群2中具有最高的组内相关系数（ICC）和最低的平均系统差异和中位绝对百分比误差，但在人群3中并非如此。亚组分析显示，在LDLdirect < 70 mg/dL的群体2中，LDLChoi和LDLdirect之间具有良好的一致性（ICC > 0.75）。对于高甘油三酯（> 400 mg/dL）的样本，方程准确度不同。根据国家胆固醇教育计划成人治疗组III标准与其他11个方程的分类一致性小于80%;人群1和人群2中LDLChoi的分类一致性分别为87.6%和87.4%。基于LDLdirect和甘油三酯，12个LDLcal公式的准确性因队列和亚组而异。为了准确评价LDL状态，可能需要LDLcal和/或LDLdirect的实验室特定方程。在线版本包含补充材料，可通过10.1186/s12944-021-01525-6获得。
Limited data are available for validation of low-density lipoprotein cholesterol (LDL) calculation (LDLcal) in the adult Korean population. The aim of this study was to develop and validate a new equation for LDLcal and to compare it with previous such equations in a Korean population. A new equation for LDLcal was developed (LDLChoi). LDLChoi and 11 other previously published equations were applied and compared with directly measured LDL concentration (LDLdirect) in a development cohort (population 1), an independent validation cohort in the same laboratory (population 2), and the Korea National Health and Nutrition Examination Survey 2017 cohort (population 3). Among the 12 equations, the newly-developed equation (LDLChoi = total cholesterol – 0.87 x high-density lipoprotein cholesterol – 0.13 x triglycerides) had the highest intraclass correlation coefficient (ICC) and the lowest mean systemic difference and median absolute percentage error in populations 1 and 2 but not in population 3. Subgroup analysis showed good agreement between LDLChoi and LDLdirect (ICC > 0.75) in population 2, whose LDLdirect < 70 mg/dL. For samples with high triglycerides (> 400 mg/dL), equation accuracy varied. Categorization concordance according to the National Cholesterol Education Program Adult Treatment Panel III criteria with the other 11 equations were less than 80%; that of LDLChoi was 87.6 and 87.4% in populations 1 and 2, respectively. Accuracy of 12 equations for LDLcal varied by cohort and subgroup based on LDLdirect and triglycerides. A laboratory-specific equation for LDLcal and/or LDLdirect may be needed for accurate evaluation of LDL status. The online version contains supplementary material available at 10.1186/s12944-021-01525-6.
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影响因子：
2.9
作者：
Choi H;Shim JS;Lee MH;Yoon YM;Choi DP;Kim HC
通讯作者：
Kim HC
影响因子：
2.8
作者：
Sung, Ki-Chul;Kwon, Chang Hee;Shin, Jeong-Hun
通讯作者：
Shin, Jeong-Hun
影响因子：
37.8
作者：
Miller, Michael;Stone, Neil J.;Pennathur, Subramanian
通讯作者：
Pennathur, Subramanian
影响因子：
3.5
作者：
Anandaraja, S;Narang, R;Talwar, KK
通讯作者：
Talwar, KK
影响因子：
2.2
作者：
Mendes de Cordova, Caio Mauricio;de Cordova, Mauricio Mendes
通讯作者：
de Cordova, Mauricio Mendes