Long-term effects of mild traumatic brain injury on cognitive performance.
Long-term effects of mild traumatic brain injury on cognitive performance.
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DOI：
10.3389/fnhum.2013.00030
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发表时间：
2013
影响因子：
2.9
通讯作者：
Sterr A
中科院分区：
文献类型：
--
作者：
Dean PJ;Sterr A
虽然一部分人报告轻度创伤性脑损伤（mTBI）后的慢性认知困难，但行为测试的结果并不一致。事实上，mTBI人群固有的变异性可能掩盖了微妙的认知缺陷。我们假设这种变异性可以通过解释样本中的脑震荡后综合征（PCS）来减少。36名mTBI参与者（受伤后>1年）和36名非头部受伤的对照者执行信息处理速度（起搏视觉序列加法任务，PVSAT）和工作记忆（n-Back）任务。两组均按PCS诊断进行分组（4组，所有n = 18），对照组的分类基于症状报告。mTBI和持续性PCS的参与者在n-Back和PVSAT上的错误率显著更高，除了0-Back（用作性能有效性测试）之外的每个难度水平。其他组之间没有差异。因此，在mTBI参与者中可以观察到认知缺陷，甚至在受伤后1年。仅在mTBI参与者中观察到认知表现与症状之间的相关性，表现较差与睡眠质量较低相关，此外还与较高的PCS症状，创伤后应激障碍（PTSD）和焦虑存在中等效应量关联（缺乏统计学显著性）。这些结果表明，认知能力的降低不是由于更多的症状报告本身，而是在一定程度上与初始损伤有关。此外，研究结果验证了我们的参与者分组的实用性，并证明了其减少先前研究中观察到的变异性的潜力。
Although a proportion of individuals report chronic cognitive difficulties after mild traumatic brain injury (mTBI), results from behavioral testing have been inconsistent. In fact, the variability inherent to the mTBI population may be masking subtle cognitive deficits. We hypothesized that this variability could be reduced by accounting for post-concussion syndrome (PCS) in the sample. Thirty-six participants with mTBI (>1 year post-injury) and 36 non-head injured controls performed information processing speed (Paced Visual Serial Addition Task, PVSAT) and working memory (n-Back) tasks. Both groups were split by PCS diagnosis (4 groups, all n = 18), with categorization of controls based on symptom report. Participants with mTBI and persistent PCS had significantly greater error rates on both the n-Back and PVSAT, at every difficulty level except 0-Back (used as a test of performance validity). There was no difference between any of the other groups. Therefore, a cognitive deficit can be observed in mTBI participants, even 1 year after injury. Correlations between cognitive performance and symptoms were only observed for mTBI participants, with worse performance correlating with lower sleep quality, in addition to a medium effect size association (falling short of statistical significance) with higher PCS symptoms, post-traumatic stress disorder (PTSD), and anxiety. These results suggest that the reduction in cognitive performance is not due to greater symptom report itself, but is associated to some extent with the initial injury. Furthermore, the results validate the utility of our participant grouping, and demonstrate its potential to reduce the variability observed in previous studies.
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影响因子：
--
作者：
Fos, L A;Greve, K W;Benefield, H
通讯作者：
Benefield, H
影响因子：
11
作者：
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影响因子：
2.6
作者：
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通讯作者：
Lofland, KR
DOI：
10.1080/13803390802134616
发表时间：
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影响因子：
2.2
作者：
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通讯作者：
Meulemans, Thierry
影响因子：
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作者：
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通讯作者：
Sterr, Annette