MicroRNA Signaling in Embryo Development.
MicroRNA Signaling in Embryo Development.
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DOI：
10.3390/biology6030034
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发表时间：
2017-09-14
期刊：
影响因子：
4.2
通讯作者：
Khatib H
中科院分区：
文献类型：
--
作者：
Gross N;Kropp J;Khatib H
microRNA（miRNAs）的表达对胚胎发育至关重要，并在配子发生中发挥重要作用。在胚胎发育的植入前阶段，miRNA被分泌到细胞外环境中。几种细胞类型在细胞外环境中将miRNA分泌到生物流体中。这些液体来源的miRNA已被证明可以在体内循环。稳定的转运依赖于将miRNA适当包装到细胞外囊泡（EV）中，包括外来体。这些囊泡也含有RNA、DNA和蛋白质，是细胞间通讯研究的前沿。有趣的是，已经在许多生殖液中鉴定出EV，例如子宫液，其中它们的miRNA含量被认为是母亲和孕体之间的串扰机制。本文综述了miRNAs在分子信号转导中的作用，并讨论了它们在早期胚胎发育和着床过程中的转运。
Expression of microRNAs (miRNAs) is essential for embryonic development and serves important roles in gametogenesis. miRNAs are secreted into the extracellular environment by the embryo during the preimplantation stage of development. Several cell types secrete miRNAs into biological fluids in the extracellular environment. These fluid-derived miRNAs have been shown to circulate the body. Stable transport is dependent on proper packaging of the miRNAs into extracellular vesicles (EVs), including exosomes. These vesicles, which also contain RNA, DNA and proteins, are on the forefront of research on cell-to-cell communication. Interestingly, EVs have been identified in many reproductive fluids, such as uterine fluid, where their miRNA content is proposed to serve as a mechanism of crosstalk between the mother and conceptus. Here, we review the role of miRNAs in molecular signaling and discuss their transport during early embryo development and implantation.
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通讯作者：
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3.7
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