Association of sleep disorders with subfoveal choroidal thickness in preschool children.
Association of sleep disorders with subfoveal choroidal thickness in preschool children.
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学龄前儿童睡眠障碍与中心凹下脉络膜厚度的关系
DOI：
10.1038/s41433-021-01489-y
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Shen S;Li X;Li R;Huang D;Zhao X;Zhang X;Hao Q;Sun Q;Tong H;Zheng X;Cao Y;Liu S;Zhu H;Liu H
探讨学龄前儿童睡眠障碍与黄斑中心凹下脉络膜厚度（SFCT）之间的关联。
在这项基于人群的横断面研究中，使用频域光学相干断层扫描（SD - OCT）测量60 - 72个月儿童的SFCT，并使用中文版儿童睡眠习惯问卷（CSHQ）评估睡眠障碍。进行多元线性回归分析以评估睡眠障碍与SFCT之间的关联。
共有1337名儿童（平均（标准差）年龄：66.88（3.41）个月）被纳入分析。在多变量线性分析中，较高的CSHQ总分（表明睡眠障碍可能性较高）与较薄的黄斑中心凹下脉络膜相关（β系数为 - 0.070；95%置信区间为 - 0.141至 - 0.001；P = 0.046）。当通过多变量模型分析八个CSHQ子量表得分中的每一个时，只有日间嗜睡子量表得分与SFCT呈负相关（β系数为 - 0.115；95%置信区间为 - 0.183至 - 0.046；P = 0.001）。有临床显著日间嗜睡的儿童（n = 364，27.2%）的黄斑中心凹下脉络膜明显比其他儿童薄（295.47对308.52μm，P = 0.007）。
在本研究中，学龄前儿童中只有日间嗜睡与SFCT显著相关。儿童时期睡眠障碍与儿童眼部发育之间的潜在关系需要进一步研究。
To explore the association between sleep disorders and subfoveal choroidal thickness (SFCT) in preschool children. In this population-based cross-sectional study, children aged 60–72 months were measured for SFCT using spectral-domain optical coherence tomography (SD-OCT) and for sleep disorders using the Chinese version of Children’s Sleep Habits Questionnaire (CSHQ). Multiple linear regression analyses were performed to assess the association between sleep disorders and SFCT. A total of 1337 children (mean (SD) age: 66.88 (3.41) months) were included in the analyses. In multivariable linear analysis, a higher total CSHQ score (indicating higher likelihood of sleep disorders) was associated with a thinner subfoveal choroid (beta, −0.070; 95% CI, −0.141 to −0.001; P = 0.046). When each of eight CSHQ subscale scores was analysed by the multivariable model, only the Daytime Sleepiness subscale score was negatively associated with the SFCT (beta, −0.115; 95% CI, −0.183 to −0.046; P = 0.001). The children with clinically significant daytime sleepiness (n = 364, 27.2%) had significantly thinner subfoveal choroid than other children (295.47 vs. 308.52 μm, P = 0.007). Only daytime sleepiness was significantly associated with SFCT in preschool children in this study. The potential relationship between sleep disorders during childhood and children’s ocular development needs further research.
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